node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | cpn-3 | T25C8.2.2 | F28H1.2.1 | ACTin. | Calponin-homology (CH) domain-containing protein. | 0.986 |
act-5 | cpn-4 | T25C8.2.2 | F49D11.8.1 | ACTin. | Calponin-homology (CH) domain-containing protein. | 0.987 |
act-5 | gsk-3 | T25C8.2.2 | Y18D10A.5.1 | ACTin. | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] | 0.755 |
act-5 | kin-1 | T25C8.2.2 | ZK909.2n.2 | ACTin. | cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. | 0.854 |
act-5 | spc-1 | T25C8.2.2 | K10B3.10b.1 | ACTin. | SPeCtrin. | 0.587 |
act-5 | unc-60 | T25C8.2.2 | C38C3.5.1 | ACTin. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.999 |
act-5 | vab-10 | T25C8.2.2 | ZK1151.1l.1 | ACTin. | GAR domain-containing protein. | 0.850 |
cpn-3 | act-5 | F28H1.2.1 | T25C8.2.2 | Calponin-homology (CH) domain-containing protein. | ACTin. | 0.986 |
cpn-3 | cpn-4 | F28H1.2.1 | F49D11.8.1 | Calponin-homology (CH) domain-containing protein. | Calponin-homology (CH) domain-containing protein. | 0.403 |
cpn-3 | unc-60 | F28H1.2.1 | C38C3.5.1 | Calponin-homology (CH) domain-containing protein. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.810 |
cpn-3 | vab-10 | F28H1.2.1 | ZK1151.1l.1 | Calponin-homology (CH) domain-containing protein. | GAR domain-containing protein. | 0.607 |
cpn-4 | act-5 | F49D11.8.1 | T25C8.2.2 | Calponin-homology (CH) domain-containing protein. | ACTin. | 0.987 |
cpn-4 | cpn-3 | F49D11.8.1 | F28H1.2.1 | Calponin-homology (CH) domain-containing protein. | Calponin-homology (CH) domain-containing protein. | 0.403 |
cpn-4 | unc-60 | F49D11.8.1 | C38C3.5.1 | Calponin-homology (CH) domain-containing protein. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.828 |
cpn-4 | vab-10 | F49D11.8.1 | ZK1151.1l.1 | Calponin-homology (CH) domain-containing protein. | GAR domain-containing protein. | 0.633 |
gsk-3 | act-5 | Y18D10A.5.1 | T25C8.2.2 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] | ACTin. | 0.755 |
gsk-3 | kin-1 | Y18D10A.5.1 | ZK909.2n.2 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] | cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. | 0.973 |
gsk-3 | unc-60 | Y18D10A.5.1 | C38C3.5.1 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.402 |
kin-1 | act-5 | ZK909.2n.2 | T25C8.2.2 | cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. | ACTin. | 0.854 |
kin-1 | gsk-3 | ZK909.2n.2 | Y18D10A.5.1 | cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] | 0.973 |