STRINGSTRING
alh-2 alh-2 alh-1 alh-1 alh-7 alh-7 alh-11 alh-11 sto-5 sto-5 fis-1 fis-1 sel-12 sel-12 lrp-1 lrp-1 gpx-1 gpx-1 hmgr-1 hmgr-1 sto-6 sto-6 pink-1 pink-1 alh-10 alh-10 hop-1 hop-1 hsp-70 hsp-70 dyn-1 dyn-1 Y73B6BL.12 Y73B6BL.12 atg-4.2 atg-4.2 spe-4 spe-4 cua-1 cua-1 atg-4.1 atg-4.1 atg-5 atg-5 alh-12 alh-12 sbp-1 sbp-1 trx-4 trx-4 cul-3 cul-3 act-5 act-5 alh-5 alh-5 alh-4 alh-4 ctc-1 ctc-1 atg-7 atg-7 pdr-1 pdr-1 alh-6 alh-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
alh-2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (514 aa)
alh-1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (510 aa)
alh-7Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (493 aa)
alh-11Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (687 aa)
sto-5PHB domain-containing protein. (381 aa)
fis-1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
lrp-1Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family. (4753 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
hmgr-13-hydroxy-3-methylglutaryl coenzyme A reductase. (550 aa)
sto-6PHB domain-containing protein. (298 aa)
pink-1Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa)
alh-10Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (506 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
dyn-1Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa)
Y73B6BL.12Thioredoxin; Belongs to the thioredoxin family. (136 aa)
atg-4.2Cysteine protease atg-4.2; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.1, but it cleaves lgg-1 precursors less efficiently than atg-4.1 (Probable). In contrast to atg-4.1, plays a more significant role in the later phases of autophagy and [...] (521 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
cua-1Copper transporting ATPase. (1238 aa)
atg-4.1Cysteine protease atg-4.1; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.2, but it cleaves lgg-1 precursors more efficiently than atg-4.2 (Probable). Acts redundantly with atg-4.2 to promote the lgg-1 delipidation to release the protein fro [...] (481 aa)
atg-5Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] (275 aa)
alh-12Aldedh domain-containing protein. (499 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
trx-4Thioredoxin; Belongs to the thioredoxin family. (107 aa)
cul-3Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] (777 aa)
act-5ACTin. (375 aa)
alh-5Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa)
alh-4Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
ctc-1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (525 aa)
atg-7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (647 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa)
alh-6Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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