STRINGSTRING
plk-3 plk-3 cdk-4 cdk-4 lin-54 lin-54 lin-9 lin-9 lin-52 lin-52 plk-2 plk-2 air-1 air-1 cdk-2 cdk-2 plk-1 plk-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
plk-3Serine/threonine-protein kinase plk-3; May be required for cell division and may have a role during G1 or S phase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (615 aa)
cdk-4Cyclin-dependent kinase 4 homolog; Serine/threonine-protein kinase which, in association with cyclin D-like protein cyd-1, is required for the progression through the G1 phase of the cell cycle during postembryonic development by phosphorylating and inhibiting lin-35 and fzr-1. In complex with cyd-1, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP). (406 aa)
lin-54Protein lin-54; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription; Belongs to the lin-54 family. (435 aa)
lin-9Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. (644 aa)
lin-52Protein lin-52; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis. Belongs to the lin-52 family. (161 aa)
plk-2Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] (632 aa)
air-1Protein kinase domain-containing protein. (326 aa)
cdk-2Cyclin-dependent kinase 2; Serine/threonine-protein kinase which, in association with cye-1, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. . In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. Phosphorylation and inhibition of the translational repressor gld-1 by the cdk-2/cye-1 complex regulates the pool of germline stem cells and the size of the mitotic zone in the gonads by preventing entry into meiosis. (338 aa)
plk-1Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] (649 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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