(32 nodes) (2018) Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans. network (Caenorhabditis elegans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	dbl-1	TGF_BETA_2 domain-containing protein. (365 aa)
	abu-1	Activated in Blocked Unfolded protein response. (425 aa)
	nlp-29	Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family. (73 aa)
	pmk-1	Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
	abu-8	Activated in Blocked Unfolded protein response. (445 aa)
	abu-15	Activated in Blocked Unfolded protein response. (388 aa)
	abu-6	Activated in Blocked Unfolded protein response. (388 aa)
	abu-7	Activated in Blocked Unfolded protein response. (438 aa)
	ser-7	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
	catp-3	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1054 aa)
	dop-6	G_PROTEIN_RECEP_F1_2 domain-containing protein. (682 aa)
	C29F3.7	CUB_2 domain-containing protein. (491 aa)
	npr-1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa)
	ced-3	Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
	dop-4	Dopamine receptor 4; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. (517 aa)
	irg-4	CUB_2 domain-containing protein. (345 aa)
	octr-1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (408 aa)
	dop-1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (460 aa)
	rgef-1	Rap Guanine nucleotide Exchange Factor homolog. (654 aa)
	irg-5	CUB_2 domain-containing protein. (343 aa)
	abu-12	Activated in Blocked Unfolded protein response. (824 aa)
	abu-13	Activated in Blocked Unfolded protein response. (493 aa)
	ser-1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa)
	tbh-1	Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (657 aa)
	tdc-1	Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family. (705 aa)
	ser-3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (610 aa)
	dop-5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (763 aa)
	asm-3	Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (589 aa)
	Y42A5A.3	Uncharacterized protein. (114 aa)
	ser-6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
	ins-7	Probable insulin-like peptide beta-type 4. (116 aa)
	lips-6	LIPaSe related. (344 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C29F3.7	Y42A5A.3	C29F3.7a.1	Y42A5A.3.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.767
C29F3.7	abu-12	C29F3.7a.1	F52D1.3b.1	CUB_2 domain-containing protein.	Activated in Blocked Unfolded protein response.	0.695
C29F3.7	abu-13	C29F3.7a.1	F57B9.9.1	CUB_2 domain-containing protein.	Activated in Blocked Unfolded protein response.	0.669
C29F3.7	abu-15	C29F3.7a.1	C03A7.4.1	CUB_2 domain-containing protein.	Activated in Blocked Unfolded protein response.	0.632
C29F3.7	abu-6	C29F3.7a.1	C03A7.7.1	CUB_2 domain-containing protein.	Activated in Blocked Unfolded protein response.	0.468
C29F3.7	catp-3	C29F3.7a.1	C09H5.2a.1	CUB_2 domain-containing protein.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.510
C29F3.7	irg-4	C29F3.7a.1	F08G5.6.2	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.761
C29F3.7	irg-5	C29F3.7a.1	F35E12.5.1	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.603
Y42A5A.3	C29F3.7	Y42A5A.3.1	C29F3.7a.1	Uncharacterized protein.	CUB_2 domain-containing protein.	0.767
Y42A5A.3	abu-1	Y42A5A.3.1	AC3.3.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.662
Y42A5A.3	abu-12	Y42A5A.3.1	F52D1.3b.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.809
Y42A5A.3	abu-13	Y42A5A.3.1	F57B9.9.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.807
Y42A5A.3	abu-15	Y42A5A.3.1	C03A7.4.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.758
Y42A5A.3	abu-6	Y42A5A.3.1	C03A7.7.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.694
Y42A5A.3	abu-7	Y42A5A.3.1	C03A7.8.1	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.660
Y42A5A.3	abu-8	Y42A5A.3.1	C03A7.14.2	Uncharacterized protein.	Activated in Blocked Unfolded protein response.	0.660
Y42A5A.3	asm-3	Y42A5A.3.1	W03G1.7a.1	Uncharacterized protein.	Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.660
Y42A5A.3	catp-3	Y42A5A.3.1	C09H5.2a.1	Uncharacterized protein.	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.715
Y42A5A.3	irg-4	Y42A5A.3.1	F08G5.6.2	Uncharacterized protein.	CUB_2 domain-containing protein.	0.478
Y42A5A.3	irg-5	Y42A5A.3.1	F35E12.5.1	Uncharacterized protein.	CUB_2 domain-containing protein.	0.465