| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| R06A4.2 | sun-1 | R06A4.2.1 | F57B1.2.1 | Uncharacterized protein. | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. | 0.471 |
| ZK430.5 | coh-3 | ZK430.5.1 | F08H9.1.1 | Peptidase C50 domain-containing protein. | Rad21_Rec8 domain-containing protein. | 0.806 |
| ZK430.5 | coh-4 | ZK430.5.1 | Y45G5AM.8a.1 | Peptidase C50 domain-containing protein. | Rad21_Rec8 domain-containing protein. | 0.698 |
| ZK430.5 | smc-3 | ZK430.5.1 | Y47D3A.26b.1 | Peptidase C50 domain-containing protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.984 |
| ZK430.5 | spo-11 | ZK430.5.1 | T05E11.4a.1 | Peptidase C50 domain-containing protein. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.827 |
| ZK430.5 | wapl-1 | ZK430.5.1 | R08C7.10b.1 | Peptidase C50 domain-containing protein. | Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] | 0.702 |
| coh-3 | ZK430.5 | F08H9.1.1 | ZK430.5.1 | Rad21_Rec8 domain-containing protein. | Peptidase C50 domain-containing protein. | 0.806 |
| coh-3 | coh-4 | F08H9.1.1 | Y45G5AM.8a.1 | Rad21_Rec8 domain-containing protein. | Rad21_Rec8 domain-containing protein. | 0.582 |
| coh-3 | sep-1 | F08H9.1.1 | Y47G6A.12.2 | Rad21_Rec8 domain-containing protein. | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | 0.843 |
| coh-3 | smc-3 | F08H9.1.1 | Y47D3A.26b.1 | Rad21_Rec8 domain-containing protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.854 |
| coh-3 | spo-11 | F08H9.1.1 | T05E11.4a.1 | Rad21_Rec8 domain-containing protein. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.762 |
| coh-3 | sun-1 | F08H9.1.1 | F57B1.2.1 | Rad21_Rec8 domain-containing protein. | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. | 0.569 |
| coh-3 | wapl-1 | F08H9.1.1 | R08C7.10b.1 | Rad21_Rec8 domain-containing protein. | Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] | 0.825 |
| coh-4 | ZK430.5 | Y45G5AM.8a.1 | ZK430.5.1 | Rad21_Rec8 domain-containing protein. | Peptidase C50 domain-containing protein. | 0.698 |
| coh-4 | coh-3 | Y45G5AM.8a.1 | F08H9.1.1 | Rad21_Rec8 domain-containing protein. | Rad21_Rec8 domain-containing protein. | 0.582 |
| coh-4 | sep-1 | Y45G5AM.8a.1 | Y47G6A.12.2 | Rad21_Rec8 domain-containing protein. | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | 0.716 |
| coh-4 | smc-3 | Y45G5AM.8a.1 | Y47D3A.26b.1 | Rad21_Rec8 domain-containing protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.889 |
| coh-4 | spo-11 | Y45G5AM.8a.1 | T05E11.4a.1 | Rad21_Rec8 domain-containing protein. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.715 |
| coh-4 | wapl-1 | Y45G5AM.8a.1 | R08C7.10b.1 | Rad21_Rec8 domain-containing protein. | Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene [...] | 0.814 |
| sep-1 | coh-3 | Y47G6A.12.2 | F08H9.1.1 | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | Rad21_Rec8 domain-containing protein. | 0.843 |