STRINGSTRING
nrde-3 nrde-3 henn-1 henn-1 hrde-1 hrde-1 eri-6 eri-6 rrf-3 rrf-3 prde-1 prde-1 ekl-1 ekl-1 ego-1 ego-1 rrf-1 rrf-1 drsh-1 drsh-1 snpc-4 snpc-4 tofu-4 tofu-4 wago-4 wago-4 hpl-2 hpl-2 parn-1 parn-1 wago-1 wago-1 ergo-1 ergo-1 gtsf-1 gtsf-1 eri-1 eri-1 eri-5 eri-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nrde-3Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. (1057 aa)
henn-1Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa)
hrde-1Uncharacterized protein C16C10.3. (1032 aa)
eri-6Enhanced RNAI (RNA interference). (360 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
prde-1piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility. (526 aa)
ekl-1Uncharacterized protein. (606 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
rrf-1RNA-dependent RNA polymerase Family. (1601 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
snpc-4snRNA-activating protein complex subunit 4 homolog; Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs. (944 aa)
tofu-4Twenty One u-rna (21U-RNA) biogenesis Fouled Up. (412 aa)
wago-4Argonaute protein wago-4; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes. Belongs to the argonaute family. WAGO subfamily. (965 aa)
hpl-2Chromo domain-containing protein. (303 aa)
parn-13'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa)
wago-1Argonaute protein wago-1; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G- RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts. (945 aa)
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)
gtsf-1CHHC U11-48K-type domain-containing protein. (169 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
eri-5Tudor domain-containing protein. (531 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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