STRINGSTRING
cpn-3 cpn-3 cpn-4 cpn-4 unc-73 unc-73 sdn-1 sdn-1 rac-2 rac-2 lect-2 lect-2 unc-70 unc-70 act-4 act-4 hpo-30 hpo-30 wve-1 wve-1 dma-1 dma-1 dpy-10 dpy-10 unc-40 unc-40 act-5 act-5 mnr-1 mnr-1 ZK970.8 ZK970.8 mig-1 mig-1 unc-44 unc-44 ser-2 ser-2 ced-10 ced-10 tiam-1 tiam-1 sax-7 sax-7 mig-2 mig-2 nlg-1 nlg-1 unc-115 unc-115 kpc-1 kpc-1 tba-1 tba-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpn-3Calponin-homology (CH) domain-containing protein. (142 aa)
cpn-4Calponin-homology (CH) domain-containing protein. (154 aa)
unc-73Guanine nucleotide exchange factor UNC-73A. (2488 aa)
sdn-1Probable syndecan; Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons. (288 aa)
rac-2Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa)
lect-2Peptidase_M23 domain-containing protein. (335 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
hpo-30Uncharacterized protein. (279 aa)
wve-1WH2 domain-containing protein. (468 aa)
dma-1LRRCT domain-containing protein. (603 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
unc-40Unc-40 protein. (1415 aa)
act-5ACTin. (375 aa)
mnr-1MeNoRin (Dendritic branching protein). (530 aa)
ZK970.8Uncharacterized protein. (143 aa)
mig-1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
unc-44Uncharacterized protein. (6994 aa)
ser-2Tyramine receptor Ser-2; G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. The rank order of potency is tyramine > octopamine > dopamine > serotonin > epinephrine = norepinephrine. (455 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
tiam-1DH domain-containing protein. (889 aa)
sax-7Fibronectin type-III domain-containing protein. (1331 aa)
mig-2Rac-like GTPase. (195 aa)
nlg-1Neuroligin-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission. Belongs to the type-B carboxylesterase/lipase family. (847 aa)
unc-115Uncharacterized protein. (639 aa)
kpc-1Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...] (692 aa)
tba-1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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