STRINGSTRING
gpd-3 gpd-3 smc-5 smc-5 C46A5.4 C46A5.4 set-8 set-8 gpd-4 gpd-4 cul-4 cul-4 pxn-2 pxn-2 gpd-2 gpd-2 ddb-1 ddb-1 cdt-2 cdt-2 T06D8.10 T06D8.10 gpd-1 gpd-1 pcn-1 pcn-1 cand-1 cand-1 cdt-1 cdt-1 pxn-1 pxn-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpd-3Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa)
smc-5Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. (1076 aa)
C46A5.4Uncharacterized protein. (1537 aa)
set-8SET domain-containing protein. (512 aa)
gpd-4Glyceraldehyde-3-phosphate dehydrogenase 4. (341 aa)
cul-4Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. (840 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
gpd-2Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa)
ddb-1DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. (1134 aa)
cdt-2WD_REPEATS_REGION domain-containing protein. (682 aa)
T06D8.10Uncharacterized protein. (1490 aa)
gpd-1Glyceraldehyde-3-phosphate dehydrogenase 1. (341 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
cand-1Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable). (1274 aa)
cdt-1CDT1 domain-containing protein. (684 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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