STRINGSTRING
mex-5 mex-5 act-5 act-5 ect-2 ect-2 sas-7 sas-7 ZK970.8 ZK970.8 such-1 such-1 rho-1 rho-1 tbb-2 tbb-2 tba-2 tba-2 pkc-3 pkc-3 sas-4 sas-4 unc-54 unc-54 nmy-2 nmy-2 spd-2 spd-2 fem-1 fem-1 tbg-1 tbg-1 spd-5 spd-5 rga-3 rga-3 unc-119 unc-119 cdc-42 cdc-42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mex-5Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. (468 aa)
act-5ACTin. (375 aa)
ect-2ECT2 (Mammalian Rho GEF) homolog. (932 aa)
sas-7Uncharacterized protein. (1013 aa)
ZK970.8Uncharacterized protein. (143 aa)
such-1Suppressor of spindle checkpoint defect 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells. Belongs to the APC5 family. (798 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
tbb-2Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (450 aa)
tba-2Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa)
sas-4Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. (808 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
spd-2Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa)
fem-1Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1. (656 aa)
tbg-1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (444 aa)
spd-5Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. (1198 aa)
rga-3Rho-GAP domain-containing protein. (1085 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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