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air-2 air-2 lab-1 lab-1 hrde-1 hrde-1 sgo-1 sgo-1 prg-1 prg-1 rsd-6 rsd-6 htp-1 htp-1 rsd-2 rsd-2 gsp-2 gsp-2 nrde-2 nrde-2 rec-8 rec-8 spr-5 spr-5
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
air-2Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa)
lab-1Long arms of the bivalent protein 1; Involved in sister chromatid cohesion during mitosis and meiosis. In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. This in turn, drives germ cell immortality. Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis. (161 aa)
hrde-1Uncharacterized protein C16C10.3. (1032 aa)
sgo-1Shugoshin; Component of cell cycle checkpoints, which ensures chromosome segregation during meiosis and mitosis. During meiotic prophase, it is involved in the regulation of the synapsis checkpoint, which monitors whether homologous chromosomes have synapsed, and the DNA damage response. Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex after prophase, when most of cohesin complex dissociates from chromosomes arms (By similarity). Belongs to the shugoshin family. (309 aa)
prg-1Piwi-like protein; Belongs to the argonaute family. (824 aa)
rsd-6Tudor domain-containing protein. (689 aa)
htp-1HORMA domain-containing protein. (352 aa)
rsd-2RSD-2 domain-containing protein. (1319 aa)
gsp-2Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...] (333 aa)
nrde-2Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family. (1270 aa)
rec-8Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. (781 aa)
spr-5Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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