STRINGSTRING
kcnl-1 kcnl-1 egl-19 egl-19 str-2 str-2 kvs-1 kvs-1 cca-1 cca-1 slo-2 slo-2 egl-2 egl-2 irk-1 irk-1 srx-3 srx-3 egl-36 egl-36 unc-2 unc-2 kqt-3 kqt-3 shk-1 shk-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kcnl-1CaMBD domain-containing protein. (792 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1877 aa)
str-2Seven transmembrane receptor 2. (358 aa)
kvs-1Uncharacterized protein; Belongs to the potassium channel family. (495 aa)
cca-1Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1885 aa)
slo-2Ion_trans_2 domain-containing protein. (1143 aa)
egl-2Uncharacterized protein. (959 aa)
irk-1Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
srx-37TM_GPCR_Srx domain-containing protein. (349 aa)
egl-36Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. (558 aa)
unc-2EF-hand domain-containing protein. (2171 aa)
kqt-3Potassium channel, KvQLT family; Belongs to the potassium channel family. (621 aa)
shk-1Potassium voltage-gated channel protein shk-1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d. (536 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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