STRINGSTRING
his-58 his-58 his-48 his-48 ced-10 ced-10 dlg-1 dlg-1 unc-54 unc-54 clec-110 clec-110 nmy-2 nmy-2 clec-233 clec-233 F46A8.3 F46A8.3 aman-2 aman-2 famk-1 famk-1 unc-119 unc-119 dpy-10 dpy-10 act-5 act-5 hmr-1 hmr-1 clec-104 clec-104 his-72 his-72 clec-100 clec-100 clec-261 clec-261 sth-1 sth-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-58Probable histone H2B 4. (123 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
dlg-1Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. (967 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
clec-110C-type LECtin. (244 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
clec-233C-type lectin domain-containing protein. (282 aa)
F46A8.3Galectin. (228 aa)
aman-2Alpha-mann_mid domain-containing protein. (1145 aa)
famk-1Extracellular serine/threonine protein kinase CeFam20; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. Belongs to the FAM20 family. (512 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
act-5ACTin. (375 aa)
hmr-1Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton. Isoform b is involved in axonal guidance in a subset of motor neurons. (2920 aa)
clec-104C-type lectin domain-containing protein. (241 aa)
his-72Histone H3.3 type 2. (151 aa)
clec-100C-type lectin domain-containing protein. (201 aa)
clec-261C-type lectin domain-containing protein. (230 aa)
sth-1SpermaTHecal expression. (119 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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