node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y37A1B.5 | egl-27 | Y37A1B.5a.1 | C04A2.3a.1 | Uncharacterized protein. | Egg-laying defective protein 27; Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. | 0.461 |
Y73B6BL.12 | daf-16 | Y73B6BL.12.1 | R13H8.1h.1 | Thioredoxin; Belongs to the thioredoxin family. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.571 |
Y73B6BL.12 | gpx-1 | Y73B6BL.12.1 | F26E4.12.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. | 0.920 |
Y73B6BL.12 | gpx-2 | Y73B6BL.12.1 | R05H10.5b.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. | 0.859 |
Y73B6BL.12 | gpx-3 | Y73B6BL.12.1 | C11E4.2.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. | 0.859 |
Y73B6BL.12 | gpx-4 | Y73B6BL.12.1 | Y94H6A.4.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.856 |
Y73B6BL.12 | gpx-5 | Y73B6BL.12.1 | C11E4.1.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.779 |
Y73B6BL.12 | gpx-6 | Y73B6BL.12.1 | T09A12.2b.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.822 |
Y73B6BL.12 | gpx-7 | Y73B6BL.12.1 | R03G5.5a.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.822 |
Y73B6BL.12 | gpx-8 | Y73B6BL.12.1 | F55A3.5.1 | Thioredoxin; Belongs to the thioredoxin family. | Glutathione PeroXidase. | 0.823 |
Y73B6BL.12 | skn-1 | Y73B6BL.12.1 | T19E7.2a.1 | Thioredoxin; Belongs to the thioredoxin family. | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] | 0.588 |
Y73B6BL.12 | trx-4 | Y73B6BL.12.1 | Y44E3A.3.1 | Thioredoxin; Belongs to the thioredoxin family. | Thioredoxin; Belongs to the thioredoxin family. | 0.621 |
Y73B6BL.12 | trxr-1 | Y73B6BL.12.1 | C06G3.7a.1 | Thioredoxin; Belongs to the thioredoxin family. | Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. | 0.965 |
cdc-42 | daf-16 | R07G3.1.1 | R13H8.1h.1 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.510 |
cdc-42 | pmp-3 | R07G3.1.1 | C54G10.3b.1 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] | Peroxisomal Membrane Protein related. | 0.866 |
cdc-42 | rol-6 | R07G3.1.1 | T01B7.7.2 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] | Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. | 0.585 |
cdc-42 | tba-1 | R07G3.1.1 | F26E4.8b.1 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. | 0.764 |
daf-16 | Y73B6BL.12 | R13H8.1h.1 | Y73B6BL.12.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Thioredoxin; Belongs to the thioredoxin family. | 0.571 |
daf-16 | cdc-42 | R13H8.1h.1 | R07G3.1.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] | 0.510 |
daf-16 | egl-27 | R13H8.1h.1 | C04A2.3a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Egg-laying defective protein 27; Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. | 0.554 |