node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
asah-1 | asah-2 | K11D2.2.1 | F27E5.1.1 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.941 |
asah-1 | lipl-1 | K11D2.2.1 | F54F3.3.1 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.482 |
asah-1 | lipl-3 | K11D2.2.1 | R11G11.14.1 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.406 |
asah-2 | asah-1 | F27E5.1.1 | K11D2.2.1 | Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. | 0.941 |
atg-13 | daf-16 | D2007.5.1 | R13H8.1h.1 | Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.524 |
atg-13 | hlh-30 | D2007.5.1 | W02C12.3c.1 | Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily. | BHLH domain-containing protein. | 0.576 |
daf-16 | atg-13 | R13H8.1h.1 | D2007.5.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily. | 0.524 |
daf-16 | hlh-30 | R13H8.1h.1 | W02C12.3c.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | BHLH domain-containing protein. | 0.939 |
daf-16 | lipl-4 | R13H8.1h.1 | K04A8.5a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.806 |
daf-16 | nhr-49 | R13H8.1h.1 | K10C3.6c.2 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.821 |
daf-16 | nhr-80 | R13H8.1h.1 | H10E21.3b.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Nuclear Hormone Receptor family. | 0.811 |
hlh-30 | atg-13 | W02C12.3c.1 | D2007.5.1 | BHLH domain-containing protein. | Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily. | 0.576 |
hlh-30 | daf-16 | W02C12.3c.1 | R13H8.1h.1 | BHLH domain-containing protein. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.939 |
hlh-30 | lipl-1 | W02C12.3c.1 | F54F3.3.1 | BHLH domain-containing protein. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.809 |
hlh-30 | lipl-3 | W02C12.3c.1 | R11G11.14.1 | BHLH domain-containing protein. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.812 |
hlh-30 | lipl-4 | W02C12.3c.1 | K04A8.5a.1 | BHLH domain-containing protein. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.741 |
hlh-30 | nhr-49 | W02C12.3c.1 | K10C3.6c.2 | BHLH domain-containing protein. | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.790 |
hlh-30 | nhr-80 | W02C12.3c.1 | H10E21.3b.1 | BHLH domain-containing protein. | Nuclear Hormone Receptor family. | 0.743 |
lbp-8 | lipl-1 | T22G5.6.1 | F54F3.3.1 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.459 |
lbp-8 | lipl-4 | T22G5.6.1 | K04A8.5a.1 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.850 |