STRINGSTRING
cdk-8 cdk-8 elt-2 elt-2 paqr-1 paqr-1 nhr-64 nhr-64 numr-2 numr-2 numr-1 numr-1 fat-7 fat-7 tba-1 tba-1 cdr-1 cdr-1 sun-1 sun-1 nhr-49 nhr-49 mtl-1 mtl-1 let-70 let-70 mdt-15 mdt-15 daf-16 daf-16 mtl-2 mtl-2 cdf-2 cdf-2 skn-1 skn-1 fat-6 fat-6 ttm-1 ttm-1 zip-4 zip-4 sbp-1 sbp-1 hsf-1 hsf-1 hizr-1 hizr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
cdk-8Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...] (588 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
paqr-1Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family. (440 aa)
nhr-64Nuclear hormone receptor family member nhr-64; Orphan nuclear receptor. (375 aa)
numr-2NUclear localized Metal Responsive. (281 aa)
numr-1NUclear localized Metal Responsive. (281 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
tba-1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
cdr-1Cadmium-inducible lysosomal protein CDR-1. (277 aa)
sun-1Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
let-70Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
mtl-2Metallothionein-2; This protein binds cations of several transition elements. (63 aa)
cdf-2Cation Diffusion Facilitator family. (360 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
ttm-1Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway. (410 aa)
zip-4BZIP domain-containing protein. (318 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
hizr-1High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated. (413 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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