STRINGSTRING
his-38 his-38 his-46 his-46 his-37 his-37 his-50 his-50 ercc-1 ercc-1 his-31 his-31 his-64 his-64 cec-5 cec-5 cul-4 cul-4 his-5 his-5 his-56 his-56 his-60 his-60 chd-1 chd-1 hpl-2 hpl-2 his-18 his-18 his-28 his-28 hpl-1 hpl-1 smo-1 smo-1 dcr-1 dcr-1 ddb-1 ddb-1 hsr-9 hsr-9 his-1 his-1 his-67 his-67 pcn-1 pcn-1 Y37B11A.2 Y37B11A.2 pola-1 pola-1 xpc-1 xpc-1 his-26 his-26 his-10 his-10 his-14 his-14 rad-23 rad-23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-38Histone H4. (103 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
his-37Histone H4. (103 aa)
his-50Histone H4. (103 aa)
ercc-1ERCC (DNA excision repair protein) homolog. (262 aa)
his-31Histone H4. (103 aa)
his-64Histone H4. (103 aa)
cec-5Chromo domain-containing protein. (374 aa)
cul-4Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. (840 aa)
his-5Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-60Histone H4. (103 aa)
chd-1Chromodomain and Helicase Domain protein. (1461 aa)
hpl-2Chromo domain-containing protein. (303 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
hpl-1Heterochromatin protein 1 homolog. (184 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
ddb-1DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. (1134 aa)
hsr-9Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation. (1165 aa)
his-1Histone H4. (103 aa)
his-67Histone H4. (103 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
Y37B11A.2DNA polymerase. (1303 aa)
pola-1DNA polymerase. (1456 aa)
xpc-1XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog. (1119 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-14Histone H4. (103 aa)
rad-23Uncharacterized protein. (323 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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