Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

CHORD containing protein.

Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family.

ACTin.

Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family.

ACTin.

Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

ACTin.

Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family.

ACTin.

Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...]

ACTin.

Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...]

ACTin.

Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family.

ACTin.

Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.

ACTin.

Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling.

ACTin.

Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.

ACTin.

Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...]

ACTin.

Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

ACTin.

BZIP domain-containing protein.

SEC7 domain-containing protein.

CHORD containing protein.

SEC7 domain-containing protein.

Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...]

SEC7 domain-containing protein.

Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family.

SEC7 domain-containing protein.

Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord.

SEC7 domain-containing protein.

Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.

SEC7 domain-containing protein.

Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.