STRINGSTRING
syx-6 syx-6 C46A5.4 C46A5.4 pxn-1 pxn-1 cnx-1 cnx-1 pat-3 pat-3 rabx-5 rabx-5 eea-1 eea-1 moc-1 moc-1 T06D8.10 T06D8.10 dab-1 dab-1 rme-6 rme-6 pxn-2 pxn-2 rab-5 rab-5 casy-1 casy-1 dyn-1 dyn-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
syx-6Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (122 aa)
C46A5.4Uncharacterized protein. (1537 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
cnx-1Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa)
pat-3Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa)
rabx-5RAB eXchange factor. (517 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
moc-1Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (435 aa)
T06D8.10Uncharacterized protein. (1490 aa)
dab-1PID domain-containing protein. (492 aa)
rme-6Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
rab-5RAB family. (208 aa)
casy-1CAlSYntenin/Alcadein homolog. (984 aa)
dyn-1Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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