STRINGSTRING
ttx-1 ttx-1 dcar-1 dcar-1 ceh-36 ceh-36 npr-1 npr-1 gcy-8 gcy-8 str-2 str-2 odr-10 odr-10 glp-1 glp-1 rrf-3 rrf-3 fat-7 fat-7 octr-1 octr-1 acs-2 acs-2 rict-1 rict-1 sra-13 sra-13 alh-6 alh-6 dgat-2 dgat-2 ser-1 ser-1 nhr-80 nhr-80 nhr-49 nhr-49 lipl-3 lipl-3 mdt-15 mdt-15 gpa-4 gpa-4 daf-9 daf-9 fat-6 fat-6 hlh-30 hlh-30 fat-5 fat-5 ser-4 ser-4 acdh-11 acdh-11 sbp-1 sbp-1 daf-2 daf-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ttx-1Homeobox domain-containing protein. (391 aa)
dcar-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (396 aa)
ceh-36Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa)
npr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa)
gcy-8Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. (1152 aa)
str-2Seven transmembrane receptor 2. (358 aa)
odr-10Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family. (339 aa)
glp-1Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
octr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (408 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
rict-1RICTOR_V domain-containing protein. (1580 aa)
sra-13Serpentine receptor class alpha-13; Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit; Belongs to the nematode receptor-like protein sra family. (335 aa)
alh-6Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
dgat-2Acyl-CoA:DiacylGlycerol AcylTransferase. (345 aa)
ser-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
lipl-3Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
gpa-4Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (359 aa)
daf-9Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
hlh-30BHLH domain-containing protein. (524 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
ser-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
acdh-11Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. (617 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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