STRINGSTRING
plk-2 plk-2 plk-1 plk-1 ruvb-1 ruvb-1 hosl-1 hosl-1 fat-7 fat-7 elo-2 elo-2 hxk-1 hxk-1 far-3 far-3 pyk-1 pyk-1 lipl-2 lipl-2 lipl-1 lipl-1 aco-2 aco-2 plk-3 plk-3 ipgm-1 ipgm-1 fum-1 fum-1 cyk-4 cyk-4 nhr-49 nhr-49 hacd-1 hacd-1 mdt-15 mdt-15 cdk-1 cdk-1 prp-19 prp-19 skn-1 skn-1 T20B12.3 T20B12.3 cts-1 cts-1 lbp-8 lbp-8 fat-6 fat-6 fat-5 fat-5 pod-2 pod-2 sbp-1 sbp-1 cyp-42A1 cyp-42A1 aco-1 aco-1 pyk-2 pyk-2 lipl-5 lipl-5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
plk-2Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] (632 aa)
plk-1Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] (649 aa)
ruvb-1RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...] (476 aa)
hosl-1Uncharacterized protein. (943 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
elo-2Elongation of very long chain fatty acids protein. (274 aa)
hxk-1Phosphotransferase; Belongs to the hexokinase family. (500 aa)
far-3Fatty Acid/Retinol binding protein. (189 aa)
pyk-1Pyruvate kinase; Belongs to the pyruvate kinase family. (913 aa)
lipl-2Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
lipl-1Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
aco-2Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (777 aa)
plk-3Serine/threonine-protein kinase plk-3; May be required for cell division and may have a role during G1 or S phase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (615 aa)
ipgm-12,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (539 aa)
fum-1Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (501 aa)
cyk-4CYtoKinesis defect. (681 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
cdk-1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (332 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
T20B12.3Uncharacterized protein T20B12.3; Belongs to the CBF/MAK21 family. (504 aa)
cts-1Probable citrate synthase, mitochondrial. (468 aa)
lbp-8FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
pod-2Uncharacterized protein. (2165 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
cyp-42A1CYtochrome P450 family; Belongs to the cytochrome P450 family. (511 aa)
aco-1Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa)
pyk-2Pyruvate kinase; Belongs to the pyruvate kinase family. (515 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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