25 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	delm-2	DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (608 aa)
	dyf-7	Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (446 aa)
	F11C7.2	Uncharacterized protein. (152 aa)
	vap-1	Venom-Allergen-like Protein; Belongs to the CRISP family. (425 aa)
	F16F9.3	EF-hand domain-containing protein. (180 aa)
	delm-1	DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (626 aa)
	daf-6	SSD domain-containing protein. (913 aa)
	itr-1	Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
	lin-48	Putative zinc finger transcription factor. (280 aa)
	hlh-17	BHLH domain-containing protein. (101 aa)
	fig-1	Uncharacterized protein. (2892 aa)
	F53F4.13	Uncharacterized protein. (114 aa)
	col-177	COLlagen. (430 aa)
	kcc-3	Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC. (1081 aa)
	col-53	COLlagen. (278 aa)
	ztf-16	Zinc finger protein ztf-16; Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons. Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology ; Belongs to the Ikaros C2H2-type zinc-finger protein family. (480 aa)
	T02B11.3	Uncharacterized protein. (198 aa)
	grl-18	Ground-like domain-containing protein. (445 aa)
	mam-5	MAM domain-containing protein. (601 aa)
	grl-2	Ground-like domain-containing protein. (365 aa)
	ver-1	Protein ver-1; Involved in amphid glia remodeling during entry into dauer stage by promoting the fusion of sheath amphid cells which encloses AWC neuron sensory endings. May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail. (1083 aa)
	itx-1	InTestinal NeureXin-like. (1645 aa)
	lit-1	Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis. (634 aa)
	ttx-1	Homeobox domain-containing protein. (391 aa)
	hmit-1.2	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (613 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F11C7.2	F16F9.3	F11C7.2.1	F16F9.3b.1	Uncharacterized protein.	EF-hand domain-containing protein.	0.864
F11C7.2	F53F4.13	F11C7.2.1	F53F4.13.1	Uncharacterized protein.	Uncharacterized protein.	0.909
F11C7.2	T02B11.3	F11C7.2.1	T02B11.3a.1	Uncharacterized protein.	Uncharacterized protein.	0.845
F11C7.2	col-177	F11C7.2.1	F59F3.2.1	Uncharacterized protein.	COLlagen.	0.894
F11C7.2	col-53	F11C7.2.1	M01A12.1.1	Uncharacterized protein.	COLlagen.	0.894
F11C7.2	delm-1	F11C7.2.1	F23B2.3.1	Uncharacterized protein.	DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.756
F11C7.2	fig-1	F11C7.2.1	F53B7.5b.1	Uncharacterized protein.	Uncharacterized protein.	0.487
F11C7.2	grl-18	F11C7.2.1	T05C3.4.1	Uncharacterized protein.	Ground-like domain-containing protein.	0.812
F11C7.2	grl-2	F11C7.2.1	T16G1.8.1	Uncharacterized protein.	Ground-like domain-containing protein.	0.700
F11C7.2	hlh-17	F11C7.2.1	F38C2.2.1	Uncharacterized protein.	BHLH domain-containing protein.	0.691
F11C7.2	hmit-1.2	F11C7.2.1	Y51A2D.5.1	Uncharacterized protein.	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.705
F11C7.2	itx-1	F11C7.2.1	W03D8.6a.1	Uncharacterized protein.	InTestinal NeureXin-like.	0.759
F11C7.2	mam-5	F11C7.2.1	T07C12.8b.1	Uncharacterized protein.	MAM domain-containing protein.	0.699
F11C7.2	vap-1	F11C7.2.1	F11C7.3a.1	Uncharacterized protein.	Venom-Allergen-like Protein; Belongs to the CRISP family.	0.644
F16F9.3	F11C7.2	F16F9.3b.1	F11C7.2.1	EF-hand domain-containing protein.	Uncharacterized protein.	0.864
F16F9.3	F53F4.13	F16F9.3b.1	F53F4.13.1	EF-hand domain-containing protein.	Uncharacterized protein.	0.922
F16F9.3	T02B11.3	F16F9.3b.1	T02B11.3a.1	EF-hand domain-containing protein.	Uncharacterized protein.	0.916
F16F9.3	col-177	F16F9.3b.1	F59F3.2.1	EF-hand domain-containing protein.	COLlagen.	0.816
F16F9.3	col-53	F16F9.3b.1	M01A12.1.1	EF-hand domain-containing protein.	COLlagen.	0.812
F16F9.3	delm-1	F16F9.3b.1	F23B2.3.1	EF-hand domain-containing protein.	DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.662