node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fasn-1 | hmgs-1 | F32H2.5.1 | F25B4.6.1 | Carrier domain-containing protein. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.657 |
fasn-1 | sbp-1 | F32H2.5.1 | Y47D3B.7.1 | Carrier domain-containing protein. | BHLH domain-containing protein. | 0.852 |
hmgs-1 | fasn-1 | F25B4.6.1 | F32H2.5.1 | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Carrier domain-containing protein. | 0.657 |
hmgs-1 | sbp-1 | F25B4.6.1 | Y47D3B.7.1 | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | BHLH domain-containing protein. | 0.571 |
hmgs-1 | ulp-1 | F25B4.6.1 | T10F2.3.1 | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.489 |
hmgs-1 | ulp-4 | F25B4.6.1 | C41C4.6.1 | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | 0.883 |
sbp-1 | fasn-1 | Y47D3B.7.1 | F32H2.5.1 | BHLH domain-containing protein. | Carrier domain-containing protein. | 0.852 |
sbp-1 | hmgs-1 | Y47D3B.7.1 | F25B4.6.1 | BHLH domain-containing protein. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.571 |
smo-1 | ubc-9 | K12C11.2.1 | F29B9.6.2 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | 0.999 |
smo-1 | ulp-1 | K12C11.2.1 | T10F2.3.1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.999 |
smo-1 | ulp-4 | K12C11.2.1 | C41C4.6.1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | 0.935 |
ubc-9 | smo-1 | F29B9.6.2 | K12C11.2.1 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.999 |
ubc-9 | ulp-1 | F29B9.6.2 | T10F2.3.1 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.943 |
ubc-9 | ulp-4 | F29B9.6.2 | C41C4.6.1 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | 0.859 |
ulp-1 | hmgs-1 | T10F2.3.1 | F25B4.6.1 | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.489 |
ulp-1 | smo-1 | T10F2.3.1 | K12C11.2.1 | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.999 |
ulp-1 | ubc-9 | T10F2.3.1 | F29B9.6.2 | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | 0.943 |
ulp-1 | ulp-4 | T10F2.3.1 | C41C4.6.1 | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | 0.951 |
ulp-4 | hmgs-1 | C41C4.6.1 | F25B4.6.1 | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.883 |
ulp-4 | smo-1 | C41C4.6.1 | K12C11.2.1 | Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis. | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.935 |