Your Input: | |
| | sulp-4 | STAS domain-containing protein. (749 aa) |
| | scc-1 | Sister chromatid cohesion protein 1; Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). (645 aa) |
| | cyk-1 | CYtoKinesis defect. (1437 aa) |
| | F12A10.7 | Protein suex-1. (113 aa) |
| | inft-2 | FH2 domain-containing protein. (1120 aa) |
| | F15E6.3 | RRM-type RNA binding protein. (118 aa) |
| | exc-9 | LIM zinc-binding domain-containing protein. (85 aa) |
| | chw-1 | CHp/Wrch Rho-like protein homolog. (207 aa) |
| | exl-1 | Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa) |
| | rab-5 | RAB family. (208 aa) |
| | daf-6 | SSD domain-containing protein. (913 aa) |
| | vha-5 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa) |
| | exc-7 | Uncharacterized protein. (456 aa) |
| | unc-6 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] (612 aa) |
| | hrp-1 | Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan. (347 aa) |
| | unc-53 | Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa) |
| | rdy-2 | Uncharacterized protein. (282 aa) |
| | rab-11.1 | Ras-related protein rab-11.1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cor [...] (211 aa) |
| | par-3 | Partitioning defective protein 3; In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo. Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces. Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca. Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first [...] (1533 aa) |
| | che-14 | SSD domain-containing protein. (917 aa) |
| | pkc-1 | Protein kinase C-like 1B; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neuro [...] (763 aa) |
| | exc-6 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa) |
| | H28G03.1 | Uncharacterized protein. (336 aa) |
| | ceh-6 | Homeobox protein ceh-6; Vital for embryonic development and essential for the proper function of the excretory cell. Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. (380 aa) |
| | ifa-4 | Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa) |
| | cdc-25.1 | M-phase inducer phosphatase cdc-25.1. (604 aa) |
| | aqp-9 | Aquaporin; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | K07A9.3 | CCM (Cerebral Cavernous Malformation) gene homolog. (255 aa) |
| | cash-1 | WD_REPEATS_REGION domain-containing protein. (678 aa) |
| | ephx-1 | EPHeXin (Eph-interacting GEF) homolog. (1159 aa) |
| | mrck-1 | Serine/threonine-protein kinase mrck-1; Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation. (1592 aa) |
| | spc-1 | SPeCtrin. (2432 aa) |
| | ifc-2 | Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa) |
| | glo-1 | Gut granule LOss. (212 aa) |
| | cdc-42 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa) |
| | eea-1 | FYVE-type domain-containing protein. (1205 aa) |
| | gck-1 | Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (803 aa) |
| | cct-2 | T-complex protein 1 subunit beta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family. (529 aa) |
| | sec-5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (884 aa) |
| | nhr-69 | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. (373 aa) |
| | act-5 | ACTin. (375 aa) |
| | par-6 | Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family. (309 aa) |
| | rab-7 | RAB family. (209 aa) |
| | dhc-4 | DHC_N2 domain-containing protein. (2727 aa) |
| | rme-1 | Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa) |
| | exc-4 | Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa) |
| | exoc-8 | Exo84_C domain-containing protein. (686 aa) |
| | pab-1 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (646 aa) |
| | mxt-1 | Eukaryotic translation initiation factor 4E-binding protein Mextli homolog; Plays a role in promoting translation. (507 aa) |
| | rho-1 | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa) |
| | mop-25.2 | MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis. (338 aa) |
| | ral-1 | RAL (Ras-related GTPase) homolog. (254 aa) |
| | gck-3 | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] (596 aa) |
| | inx-13 | Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (385 aa) |
| | kri-1 | KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog. (729 aa) |
| | sulp-8 | STAS domain-containing protein. (611 aa) |
| | aqp-11 | Aquaporin; Belongs to the MIP/aquaporin (TC 1.A.8) family. (279 aa) |
| | inx-12 | Innexin-12; Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca. Plays a role in male tail tip morphogenesis ; Belongs to the pannexin family. (408 aa) |
| | unc-5 | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa) |
| | arf-1.2 | ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa) |
| | dhc-3 | Dynein Heavy Chain. (3275 aa) |
| | erm-1 | FERM domain-containing protein. (564 aa) |
| | ccm-3 | Programmed cell death protein 10 homolog; Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility. (215 aa) |
| | sec-15 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC15 family. (817 aa) |
| | exc-5 | Uncharacterized protein. (861 aa) |
| | tbb-2 | Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (450 aa) |
| | ceh-37 | Homeobox protein ceh-37; Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons; Belongs to the paired homeobox family. (278 aa) |
| | wnk-1 | Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals. (1850 aa) |
| | exc-1 | IRG-type G domain-containing protein. (763 aa) |
| | C53B4.1 | MFS domain-containing protein. (502 aa) |
| | icd-1 | Transcription factor BTF3 homolog; May act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II. (161 aa) |
| | rab-8 | RAB family. (211 aa) |
| | ifb-1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa) |
| | farl-11 | DUF3402 domain-containing protein. (978 aa) |
