STRINGSTRING
ama-1 ama-1 elt-2 elt-2 acdh-1 acdh-1 cdc-5L cdc-5L lin-26 lin-26 msra-1 msra-1 pmt-2 pmt-2 nhr-68 nhr-68 unc-119 unc-119 metr-1 metr-1 pmp-5 pmp-5 nhr-114 nhr-114 sbp-1 sbp-1 cbs-1 cbs-1 nhr-10 nhr-10 mtrr-1 mtrr-1 nhr-23 nhr-23 mel-32 mel-32 mthf-1 mthf-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
cdc-5LCell Division Cycle related. (755 aa)
lin-26Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa)
msra-1PMSR domain-containing protein. (207 aa)
pmt-2Phosphoethanolamine MethylTransferase. (437 aa)
nhr-68NR LBD domain-containing protein. (385 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
metr-1Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1249 aa)
pmp-5ABC transmembrane type-1 domain-containing protein. (598 aa)
nhr-114NR LBD domain-containing protein; Belongs to the nuclear hormone receptor family. (418 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
cbs-1PALP domain-containing protein. (704 aa)
nhr-10Nuclear hormone receptor family member nhr-10; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (395 aa)
mtrr-1Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state. (682 aa)
nhr-23Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. (588 aa)
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa)
mthf-1Probable methylenetetrahydrofolate reductase. (663 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (10%) [HD]