30 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pmk-1	Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
	let-363	Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] (2695 aa)
	atgl-1	Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] (751 aa)
	irg-1	DUF1768 domain-containing protein. (212 aa)
	C17H12.8	CUB_2 domain-containing protein. (348 aa)
	rab-3	Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa)
	fshr-1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (932 aa)
	F01D5.5	Uncharacterized protein. (165 aa)
	glo-4	X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa)
	fat-7	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
	gly-19	GLYcosylation related. (436 aa)
	pgp-12	p-GlycoProtein related. (1318 aa)
	acs-2	Fatty Acid CoA Synthetase family. (618 aa)
	fasn-1	Carrier domain-containing protein. (2613 aa)
	ama-1	DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
	mxl-3	BHLH domain-containing protein. (235 aa)
	lipl-1	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
	F55G11.2	CUB_2 domain-containing protein. (341 aa)
	hlh-11	Helix-loop-helix protein 11. (431 aa)
	zip-2	BZIP domain-containing protein. (308 aa)
	K08D8.5	CUB_2 domain-containing protein. (334 aa)
	nhr-49	Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
	unc-119	Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
	lipl-3	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
	aak-2	5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa)
	T24B8.5	Uncharacterized protein. (99 aa)
	hlh-30	BHLH domain-containing protein. (524 aa)
	pod-2	Uncharacterized protein. (2165 aa)
	sbp-1	BHLH domain-containing protein. (1113 aa)
	eat-2	Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C17H12.8	F01D5.5	C17H12.8.2	F01D5.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.777
C17H12.8	F55G11.2	C17H12.8.2	F55G11.2.1	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.643
C17H12.8	K08D8.5	C17H12.8.2	K08D8.5.1	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.940
C17H12.8	T24B8.5	C17H12.8.2	T24B8.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.860
C17H12.8	pmk-1	C17H12.8.2	B0218.3.1	CUB_2 domain-containing protein.	Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...]	0.698
C17H12.8	zip-2	C17H12.8.2	K02F3.4.2	CUB_2 domain-containing protein.	BZIP domain-containing protein.	0.461
F01D5.5	C17H12.8	F01D5.5.1	C17H12.8.2	Uncharacterized protein.	CUB_2 domain-containing protein.	0.777
F01D5.5	F55G11.2	F01D5.5.1	F55G11.2.1	Uncharacterized protein.	CUB_2 domain-containing protein.	0.408
F01D5.5	K08D8.5	F01D5.5.1	K08D8.5.1	Uncharacterized protein.	CUB_2 domain-containing protein.	0.759
F01D5.5	T24B8.5	F01D5.5.1	T24B8.5.1	Uncharacterized protein.	Uncharacterized protein.	0.708
F01D5.5	irg-1	F01D5.5.1	C07G3.2.1	Uncharacterized protein.	DUF1768 domain-containing protein.	0.465
F01D5.5	pmk-1	F01D5.5.1	B0218.3.1	Uncharacterized protein.	Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...]	0.530
F01D5.5	zip-2	F01D5.5.1	K02F3.4.2	Uncharacterized protein.	BZIP domain-containing protein.	0.676
F55G11.2	C17H12.8	F55G11.2.1	C17H12.8.2	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.643
F55G11.2	F01D5.5	F55G11.2.1	F01D5.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.408
F55G11.2	T24B8.5	F55G11.2.1	T24B8.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.439
K08D8.5	C17H12.8	K08D8.5.1	C17H12.8.2	CUB_2 domain-containing protein.	CUB_2 domain-containing protein.	0.940
K08D8.5	F01D5.5	K08D8.5.1	F01D5.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.759
K08D8.5	T24B8.5	K08D8.5.1	T24B8.5.1	CUB_2 domain-containing protein.	Uncharacterized protein.	0.929
K08D8.5	irg-1	K08D8.5.1	C07G3.2.1	CUB_2 domain-containing protein.	DUF1768 domain-containing protein.	0.513