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hsf-1 hsf-1 nlp-31 nlp-31 nlp-77 nlp-77 pdi-2 pdi-2 hsp-70 hsp-70 pdi-1 pdi-1 hda-11 hda-11 egl-3 egl-3 mrps-5 mrps-5 ins-1 ins-1 rgba-1 rgba-1 nlp-24 nlp-24 hsp-4 hsp-4 hda-5 hda-5 argk-1 argk-1 atf-6 atf-6 pek-1 pek-1 npr-28 npr-28 kcc-3 kcc-3 hda-3 hda-3 sir-2.1 sir-2.1 daf-16 daf-16 xbp-1 xbp-1 ins-31 ins-31 nlp-51 nlp-51 hsp-60 hsp-60 nlp-17 nlp-17 rsks-1 rsks-1 hda-10 hda-10 daf-2 daf-2 ins-7 ins-7 unc-13 unc-13 unc-31 unc-31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
nlp-31Neuropeptide-like protein 31; Antimicrobial peptides that have antifungal activity against D.coniospora. Has weak antibacterial activity against Gram-positive bacteria M.luteus and Gram-negative E.coli. (75 aa)
nlp-77DUF148 domain-containing protein. (151 aa)
pdi-2Protein disulfide-isomerase 2; Involved in cuticle formation. May play a role in the unfolded protein response. Belongs to the protein disulfide isomerase family. (493 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
pdi-1Protein disulfide-isomerase 1; Belongs to the protein disulfide isomerase family. (485 aa)
hda-11Hist_deacetyl domain-containing protein. (334 aa)
egl-3Neuroendocrine convertase 2; Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. [...] (652 aa)
mrps-5Putative 28S ribosomal protein S5, mitochondrial; Belongs to the universal ribosomal protein uS5 family. (436 aa)
ins-1IlGF domain-containing protein. (109 aa)
rgba-1Regulatory Gene for Behavioral Aging. (106 aa)
nlp-24Neuropeptide-Like Protein. (80 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
hda-5Hist_deacetyl domain-containing protein. (508 aa)
argk-1ARGinine Kinase; Belongs to the ATP:guanido phosphotransferase family. (372 aa)
atf-6BZIP domain-containing protein. (589 aa)
pek-1Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1077 aa)
npr-28G_PROTEIN_RECEP_F1_2 domain-containing protein. (518 aa)
kcc-3Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC. (1081 aa)
hda-3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa)
sir-2.1NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] (607 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
xbp-1BZIP domain-containing protein. (335 aa)
ins-31INSulin related. (218 aa)
nlp-51Neuropeptide-Like Protein. (64 aa)
hsp-60Chaperonin homolog Hsp-60, mitochondrial; Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity). (568 aa)
nlp-17Neuropeptide-Like Protein. (83 aa)
rsks-1Ribosomal protein S6 kinase beta; Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm prod [...] (550 aa)
hda-10Hist_deacetyl domain-containing protein. (517 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
ins-7Probable insulin-like peptide beta-type 4. (116 aa)
unc-13Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa)
unc-31Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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