Your Input: | |
| | pgp-12 | p-GlycoProtein related. (1318 aa) |
| | ugt-1 | UDP-GlucuronosylTransferase. (529 aa) |
| | amx-2 | Amino_oxidase domain-containing protein. (724 aa) |
| | misc-1 | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Furthermore, plays a role in the oxidative stress response regulating endo [...] (306 aa) |
| | gst-33 | Glutathione S-Transferase. (213 aa) |
| | cyp-35A1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | cyp-35A2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | ugt-63 | UDP-GlucuronosylTransferase. (506 aa) |
| | pgp-5 | p-GlycoProtein related. (1252 aa) |
| | ugt-22 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa) |
| | ugt-28 | UDP-GlucuronosylTransferase. (537 aa) |
| | ugt-26 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | ugt-66 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa) |
| | aha-1 | Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons. (453 aa) |
| | elt-2 | Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa) |
| | C33F10.14 | Semialdhyde_dh domain-containing protein. (218 aa) |
| | nhr-42 | Nuclear hormone receptor family member nhr-42; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (356 aa) |
| | cyp-36A1 | Probable cytochrome P450 CYP36A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (493 aa) |
| | pgp-2 | p-GlycoProtein related. (1296 aa) |
| | ahr-1 | Aryl hydrocarbon receptor protein 1; Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance. (602 aa) |
| | nhr-46 | Nuclear Hormone Receptor family. (576 aa) |
| | ced-7 | ABC transporter ced-7; Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells. (1758 aa) |
| | alh-10 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (506 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | vhp-1 | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa) |
| | flr-4 | Serine/threonine-protein kinase flr-4; Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms. (570 aa) |
| | daf-12 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa) |
| | gst-7 | Probable glutathione S-transferase 7; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | gst-6 | Probable glutathione S-transferase 6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family. (206 aa) |
| | mrp-5 | Uncharacterized protein. (1427 aa) |
| | nhr-176 | Nuclear Hormone Receptor family. (345 aa) |
| | pgp-13 | p-GlycoProtein related. (1324 aa) |
| | pgp-14 | P-glycoprotein related (146.8 kD) (Pgp-14). (1327 aa) |
| | nhr-8 | Nuclear hormone receptor family member nhr-8; Orphan nuclear receptor. (560 aa) |
| | gst-24 | Glutathione S-Transferase. (209 aa) |
| | gst-19 | Glutathione S-Transferase. (207 aa) |
| | pha-4 | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] (506 aa) |
| | hif-1 | Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...] (721 aa) |
| | alh-11 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (687 aa) |
| | alh-7 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (493 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | alh-1 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (510 aa) |
| | alh-6 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa) |
| | mrp-1 | Uncharacterized protein. (1534 aa) |
| | unc-24 | PHB domain-containing protein. (443 aa) |
| | H19N07.3 | Uncharacterized protein. (168 aa) |
| | ugt-13 | UDP-GlucuronosylTransferase. (532 aa) |
| | ugt-8 | UDP-GlucuronosylTransferase. (531 aa) |
| | ceeh-1 | Epoxide hydrolase 1; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME). Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. (404 aa) |
| | unc-1 | Protein unc-1. (289 aa) |
| | alh-2 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (514 aa) |
| | ceeh-2 | Epoxide hydrolase 2; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME). Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. (355 aa) |
| | cyp-35B2 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | cyp-35B1 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (499 aa) |
| | pgp-1 | Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1321 aa) |
| | cyp-35A3 | CYtochrome P450 family; Belongs to the cytochrome P450 family. (494 aa) |
| | nhr-49 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa) |
| | emb-8 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (662 aa) |
| | vglu-2 | MFS domain-containing protein. (573 aa) |
| | sodh-1 | Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. (349 aa) |
| | sodh-2 | Alcohol dehydrogenase 2; Belongs to the zinc-containing alcohol dehydrogenase family. (351 aa) |
| | gst-5 | Probable glutathione S-transferase 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family. (207 aa) |
| | nac-2 | Sodium-dependent high-affinity dicarboxylate transporter 2; High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. (585 aa) |
| | mdt-15 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa) |
| | cest-1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (673 aa) |
| | alh-4 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa) |
| | ugt-50 | Putative UDP-glucuronosyltransferase ugt-50. (523 aa) |
| | alh-5 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa) |
| | slc-17.9 | MFS domain-containing protein. (516 aa) |
| | daf-9 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] (572 aa) |
| | skn-1 | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa) |
| | pgp-6 | p-GlycoProtein related. (1263 aa) |
| | alh-13 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa) |
| | skp-1 | Uncharacterized protein T27F2.1. (535 aa) |
| | hut-1 | Yeast Homolog UDP-Gal Transporter. (340 aa) |
| | ssu-1 | Sulfotransfer_1 domain-containing protein. (412 aa) |
| | nhr-86 | Nuclear hormone receptor family member nhr-86; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (407 aa) |
| | nhr-114 | NR LBD domain-containing protein; Belongs to the nuclear hormone receptor family. (418 aa) |
| | snf-5 | Sodium-dependent transporter snf-5; Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid (Probable). May additionally have a role in potassium-dependent amino acid absorption. In response to the availability of amino acid nutrients, may play a role in dauer formation. May play a role in promoting fertility. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (728 aa) |
| | Y62E10A.6 | NADPH:adrenodoxin oxidoreductase, mitochondrial. (458 aa) |
| | alh-12 | Aldedh domain-containing protein. (499 aa) |
| | Y73F8A.27 | 2Fe-2S ferredoxin-type domain-containing protein. (169 aa) |
| | ugt-16 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa) |
| | ugt-3 | UDP-GlucuronosylTransferase. (529 aa) |
| | pgp-3 | Multidrug resistance protein pgp-3; Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1268 aa) |
| | eat-4 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa) |
| | cyn-2 | Peptidyl-prolyl cis-trans isomerase 2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (172 aa) |
| | nhr-48 | Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. (817 aa) |
| | dbt-1 | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] (448 aa) |
