STRINGSTRING
spp-7 spp-7 oga-1 oga-1 jun-1 jun-1 act-5 act-5 clec-39 clec-39 clec-49 clec-49 lys-1 lys-1 clec-4 clec-4 crh-1 crh-1 clec-174 clec-174 clec-70 clec-70 eat-2 eat-2 daf-2 daf-2 clec-60 clec-60 pmk-1 pmk-1 clec-41 clec-41 lys-7 lys-7 atf-7 atf-7 unc-89 unc-89 elt-2 elt-2 clec-86 clec-86 C54G4.4 C54G4.4 clec-17 clec-17 daf-12 daf-12 unc-54 unc-54 clec-42 clec-42 clec-1 clec-1 clec-65 clec-65 irg-7 irg-7 clec-79 clec-79 unc-119 unc-119 clec-43 clec-43 daf-16 daf-16 aak-2 aak-2 mtl-2 mtl-2 dpy-10 dpy-10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spp-7SaPosin-like Protein family. (322 aa)
oga-1O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase). (872 aa)
jun-1Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. (319 aa)
act-5ACTin. (375 aa)
clec-39C-type LECtin. (405 aa)
clec-49C-type LECtin. (321 aa)
lys-1Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection. (298 aa)
clec-4C-type LECtin. (425 aa)
crh-1BZIP domain-containing protein. (428 aa)
clec-174C-type lectin domain-containing protein. (456 aa)
clec-70C-type lectin domain-containing protein. (466 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
clec-60VWFA domain-containing protein. (406 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
clec-41C-type LECtin. (545 aa)
lys-7Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa)
atf-7BZIP domain-containing protein. (509 aa)
unc-89Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
clec-86C-type lectin domain-containing protein. (166 aa)
C54G4.4Uncharacterized protein. (868 aa)
clec-17C-type LECtin. (416 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
clec-42C-type LECtin. (555 aa)
clec-1C-type lectin domain-containing protein. (173 aa)
clec-65C-type LECtin. (372 aa)
irg-7Protein irg-7; Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity. (2217 aa)
clec-79C-type lectin domain-containing protein. (575 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
clec-43C-type LECtin. (572 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
aak-25'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa)
mtl-2Metallothionein-2; This protein binds cations of several transition elements. (63 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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