STRINGSTRING
sbp-1 sbp-1 daf-2 daf-2 kin-1 kin-1 lagr-1 lagr-1 nhr-62 nhr-62 faah-4 faah-4 faah-1 faah-1 let-363 let-363 age-1 age-1 daf-15 daf-15 mlst-8 mlst-8 acdh-2 acdh-2 acdh-13 acdh-13 trpa-1 trpa-1 acdh-5 acdh-5 ras-1 ras-1 hosl-1 hosl-1 acdh-1 acdh-1 acdh-12 acdh-12 fat-7 fat-7 daf-12 daf-12 acdh-9 acdh-9 nhr-8 nhr-8 pha-4 pha-4 nhr-80 nhr-80 hyl-2 hyl-2 lipl-4 lipl-4 acdh-8 acdh-8 dgk-5 dgk-5 acdh-3 acdh-3 nhr-49 nhr-49 mdt-15 mdt-15 daf-16 daf-16 xbp-1 xbp-1 aak-2 aak-2 acdh-10 acdh-10 ocr-2 ocr-2 acdh-4 acdh-4 cav-1 cav-1 skn-1 skn-1 lbp-8 lbp-8 raga-1 raga-1 jun-1 jun-1 acdh-7 acdh-7 fat-6 fat-6 hlh-30 hlh-30 lbp-5 lbp-5 W02F12.2 W02F12.2 ragc-1 ragc-1 faah-6 faah-6 rsks-1 rsks-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sbp-1BHLH domain-containing protein. (1113 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
lagr-1Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. (360 aa)
nhr-62Nuclear hormone receptor family member nhr-62; Orphan nuclear receptor. (515 aa)
faah-4Monoglyceride lipase faah-4; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2- arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides. Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency. Plays a role in the regulation of longevity and resistance to oxidative stress. Belongs to the amidase family. (647 aa)
faah-1Fatty acid amide hydrolase 1; Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Facilitates axon regeneration after injury by degradating inh [...] (572 aa)
let-363Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] (2695 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa)
daf-15Raptor_N domain-containing protein. (1800 aa)
mlst-8WD_REPEATS_REGION domain-containing protein. (382 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
trpa-1Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. (1211 aa)
acdh-5Acyl CoA DeHydrogenase. (442 aa)
ras-1GTP binding protein. (212 aa)
hosl-1Uncharacterized protein. (943 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
nhr-8Nuclear hormone receptor family member nhr-8; Orphan nuclear receptor. (560 aa)
pha-4Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] (506 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
hyl-2Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. (329 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
acdh-8Acyl CoA DeHydrogenase. (412 aa)
dgk-5Putative diacylglycerol kinase K06A1.6. (1150 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
xbp-1BZIP domain-containing protein. (335 aa)
aak-25'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
ocr-2ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (900 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
cav-1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
lbp-8FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
raga-1RAs-related GTP-binding protein A. (312 aa)
jun-1Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. (319 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
hlh-30BHLH domain-containing protein. (524 aa)
lbp-5Fatty acid-binding protein homolog 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa)
W02F12.2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. (272 aa)
ragc-1RAs-related GTP binding protein C homolog. (338 aa)
faah-6Amidase domain-containing protein. (521 aa)
rsks-1Ribosomal protein S6 kinase beta; Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm prod [...] (550 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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