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ulp-1 | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. (697 aa) | ||||
his-45 | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) | ||||
his-48 | Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) | ||||
his-46 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) | ||||
aos-1 | SUMO-activating enzyme subunit aos-1; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable). (350 aa) | ||||
tir-1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa) | ||||
let-418 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa) | ||||
ubc-9 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa) | ||||
his-6 | Histone H3. (136 aa) | ||||
mes-3 | Polycomb protein mes-3; Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is [...] (754 aa) | ||||
his-58 | Probable histone H2B 4. (123 aa) | ||||
sun-1 | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa) | ||||
smo-1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa) | ||||
mep-1 | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. (870 aa) | ||||
unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa) | ||||
mes-2 | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] (773 aa) | ||||
gei-17 | E3 SUMO-protein ligase gei-17; Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus. (780 aa) | ||||
mes-4 | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] (898 aa) | ||||
mrg-1 | MRG domain-containing protein. (337 aa) | ||||
pie-1 | Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. (335 aa) | ||||
his-10 | Histone H4. (103 aa) | ||||
unc-22 | Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (7158 aa) |