STRINGSTRING
eat-4 eat-4 lury-1 lury-1 gpa-16 gpa-16 unc-17 unc-17 cha-1 cha-1 acr-8 acr-8 gur-3 gur-3 tph-1 tph-1 unc-13 unc-13 acr-6 acr-6 unc-31 unc-31 gur-5 gur-5 flp-15 flp-15 glr-2 glr-2 ser-7 ser-7 lite-1 lite-1 gar-1 gar-1 acr-19 acr-19 C32F10.8 C32F10.8 lev-8 lev-8 acr-9 acr-9 egl-47 egl-47 acr-11 acr-11 lev-1 lev-1 unc-54 unc-54 pbo-6 pbo-6 unc-38 unc-38 acr-16 acr-16 acr-15 acr-15 acr-21 acr-21 acr-18 acr-18 gar-2 gar-2 acr-17 acr-17 acc-3 acc-3 acc-1 acc-1 acr-23 acr-23 ser-1 ser-1 tdc-1 tdc-1 deg-3 deg-3 acr-5 acr-5 mod-1 mod-1 gur-4 gur-4 vglu-2 vglu-2 acr-2 acr-2 acr-3 acr-3 acr-12 acr-12 acr-10 acr-10 acr-20 acr-20 acr-14 acr-14 unc-29 unc-29 acr-7 acr-7 ric-3 ric-3 myo-2 myo-2 lgc-40 lgc-40 des-2 des-2 acc-4 acc-4 unc-63 unc-63 ser-4 ser-4 unc-25 unc-25 gar-3 gar-3 pbo-5 pbo-5 eat-2 eat-2 acr-24 acr-24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
lury-1Luqin-like RYamide peptides lury-1; [LURY-1-1]: Acts as a ligand for the npr-22 receptor and controls food-related processes including feeding, lifespan, egg-laying and roaming behavior. Secreted in the presence of food, leading to reduced feeding and roaming behavior and increased egg laying and lifespan. Activity may be latent under normal conditions but induced under conditions that cause hyperactivation of the pharynx such as abrupt refeeding after starvation. (89 aa)
gpa-16Guanine nucleotide-binding protein alpha-16 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Belongs to the G-alpha family. (357 aa)
unc-17Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa)
cha-1Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. (627 aa)
acr-8Acetylcholine receptor 8. (537 aa)
gur-3Gustatory receptor family protein 3; Chemoreceptor involved in light-induced avoidance behavior. Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide. Involved in circadian rhythms, probably by acting as a light sensor. In contrast to lite-1, does not act as a photoreceptor. (447 aa)
tph-1BH4_AAA_HYDROXYL_2 domain-containing protein. (532 aa)
unc-13Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa)
acr-6AcetylCholine Receptor. (551 aa)
unc-31Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa)
gur-5GUstatory Receptor family. (408 aa)
flp-15FMRF-Like Peptide. (87 aa)
glr-2Glutamate receptor 2; L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (977 aa)
ser-7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (435 aa)
lite-1High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. (439 aa)
gar-1Probable muscarinic acetylcholine receptor gar-1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (713 aa)
acr-19AcetylCholine Receptor. (560 aa)
C32F10.8Aminotran_1_2 domain-containing protein. (504 aa)
lev-8Uncharacterized protein. (531 aa)
acr-9AcetylCholine Receptor. (534 aa)
egl-47Egg laying defective EGL-47A; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (522 aa)
acr-11AcetylCholine Receptor. (461 aa)
lev-1Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
pbo-6Proton-gated ion channel subunit pbo-6; Forms a proton-gated ion channel with pbo-5 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Not necessary for stimulation of posterior body contraction (pBoc). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline. (422 aa)
unc-38Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa)
acr-16Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. (498 aa)
acr-15AcetylCholine Receptor. (479 aa)
acr-21AcetylCholine Receptor. (635 aa)
acr-18AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (510 aa)
gar-2Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] (667 aa)
acr-17AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (515 aa)
acc-3Acetylcholine-gated chloride channel subunit acc-3; Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. Belongs to the ligand-gated ion channel (TC 1.A.9) family. (517 aa)
acc-1Acetylcholine-gated chloride channel subunit acc-1; Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine. (470 aa)
acr-23Betaine receptor acr-23; Betaine receptor that functions as a ligand-gated non- selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA. (545 aa)
ser-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa)
tdc-1Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family. (705 aa)
deg-3Acetylcholine receptor subunit alpha-type deg-3; Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (564 aa)
acr-5Acetylcholine receptor subunit alpha-type acr-5; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (598 aa)
mod-1Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
gur-4GUstatory Receptor family. (413 aa)
vglu-2MFS domain-containing protein. (573 aa)
acr-2Acetylcholine receptor subunit beta-type acr-2; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (575 aa)
acr-3Acetylcholine receptor subunit beta-type acr-3; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. (487 aa)
acr-12Nicotinic acetylcholine receptor-like subunit ACR-12. (573 aa)
acr-10AcetylCholine Receptor. (557 aa)
acr-20AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (556 aa)
acr-14AcetylCholine Receptor. (500 aa)
unc-29Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa)
acr-7Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (538 aa)
ric-3Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family. (378 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
lgc-40Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (494 aa)
des-2Acetylcholine receptor subunit alpha-type des-2; Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (559 aa)
acc-4Acetylcholine-gated ion channel acc-4; Probable acetylcholine-gated chloride channel subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. (408 aa)
unc-63Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa)
ser-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
unc-25Glutamic acid decarboxylase. (508 aa)
gar-3Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. (611 aa)
pbo-5Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (509 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)
acr-24AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (578 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]