STRINGSTRING
ced-10 ced-10 egl-8 egl-8 tpa-1 tpa-1 npr-19 npr-19 pld-1 pld-1 goa-1 goa-1 daf-37 daf-37 odr-10 odr-10 maoc-1 maoc-1 srh-234 srh-234 acox-1.1 acox-1.1 acox-1.2 acox-1.2 acox-1.3 acox-1.3 acox-1.4 acox-1.4 vhp-1 vhp-1 srg-37 srg-37 srg-36 srg-36 mek-1 mek-1 mlk-1 mlk-1 egl-30 egl-30 dhs-28 dhs-28 hacd-1 hacd-1 ges-1 ges-1 kgb-1 kgb-1 srx-16 srx-16 srx-43 srx-43 srx-44 srx-44 srbc-66 srbc-66 npr-32 npr-32 max-2 max-2 srbc-64 srbc-64 daf-22 daf-22 mec-7 mec-7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
egl-81-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa)
tpa-1Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...] (704 aa)
npr-19G_PROTEIN_RECEP_F1_2 domain-containing protein. (420 aa)
pld-1Phospholipase. (1427 aa)
goa-1Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...] (354 aa)
daf-37G-protein coupled receptor daf-37; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-38 to control dauer formation and behavior. Receptor for the ascaroside pheromone ascr#2. Required for the response to dauer inducing pheromones, specifically the ascaroside ascr#2. May serve neuronal specific roles in response to ascr#2 with expression in ASI neurons controlling dauer formation in larvae, and expression in ASK neurons playing a role in longevity and hermaphrodite repulsion. May function upstream of the daf-11, daf-7 and daf-2 signaling pathways. (482 aa)
odr-10Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family. (339 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
srh-234Serpentine Receptor, class H. (334 aa)
acox-1.1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (674 aa)
acox-1.2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
acox-1.3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
acox-1.4Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
vhp-1Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa)
srg-37Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family. (324 aa)
srg-36Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family. (332 aa)
mek-1Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa)
mlk-1Mitogen-activated protein kinase kinase kinase mlk-1; Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury. (1059 aa)
egl-30Heterotrimeric G protein alpha subunit. (355 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
ges-1Gut esterase 1; Belongs to the type-B carboxylesterase/lipase family. (562 aa)
kgb-1GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa)
srx-16G_PROTEIN_RECEP_F1_2 domain-containing protein. (286 aa)
srx-43Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family. (319 aa)
srx-447TM_GPCR_Srx domain-containing protein. (322 aa)
srbc-66Serpentine Receptor, class BC (Class B-like). (286 aa)
npr-32G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
max-2Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa)
srbc-64Serpentine Receptor, class BC (Class B-like). (289 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
mec-7Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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