STRINGSTRING
rol-6 rol-6 cht-2 cht-2 pals-25 pals-25 skn-1 skn-1 chil-27 chil-27 act-5 act-5 zip-10 zip-10 zip-3 zip-3 cht-4 cht-4 zip-4 zip-4 sta-1 sta-1 zip-1 zip-1 atfs-1 atfs-1 ZK355.8 ZK355.8 pxn-1 pxn-1 gst-33 gst-33 sid-1 sid-1 cht-1 cht-1 atf-7 atf-7 pals-5 pals-5 pals-22 pals-22 C46A5.4 C46A5.4 cebp-2 cebp-2 cebp-1 cebp-1 drh-1 drh-1 lin-26 lin-26 F26F2.1 F26F2.1 F26F2.3 F26F2.3 F26F2.4 F26F2.4 F55G1.7 F55G1.7 sta-2 sta-2 K02D7.1 K02D7.1 K02E7.10 K02E7.10 zip-2 zip-2 rde-1 rde-1 pxn-2 pxn-2 daf-16 daf-16 T06D8.10 T06D8.10 math-39 math-39 snb-1 snb-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
cht-2CHiTinase; Belongs to the glycosyl hydrolase 18 family. (626 aa)
pals-25Protein containing ALS2cr12 (ALS2CR12) signature. (305 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
chil-27CHItinase-Like. (407 aa)
act-5ACTin. (375 aa)
zip-10Transcription factor zip-10; Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals. (165 aa)
zip-3BZIP domain-containing protein. (307 aa)
cht-4Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (360 aa)
zip-4BZIP domain-containing protein. (318 aa)
sta-1Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor. (706 aa)
zip-1BZIP transcription factor family. (480 aa)
atfs-1Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] (488 aa)
ZK355.8Uncharacterized protein. (61 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
gst-33Glutathione S-Transferase. (213 aa)
sid-1Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. (776 aa)
cht-1Probable endochitinase. (617 aa)
atf-7BZIP domain-containing protein. (509 aa)
pals-5Protein containing ALS2cr12 (ALS2CR12) signature. (304 aa)
pals-22Protein containing ALS2cr12 (ALS2CR12) signature. (284 aa)
C46A5.4Uncharacterized protein. (1537 aa)
cebp-2BZIP domain-containing protein. (100 aa)
cebp-1C/EBP (CCAAT/enhancer-binding protein) homolog. (319 aa)
drh-1Dicer-related helicase. (1037 aa)
lin-26Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa)
F26F2.1Uncharacterized protein. (663 aa)
F26F2.3Uncharacterized protein. (283 aa)
F26F2.4Uncharacterized protein. (93 aa)
F55G1.7Uncharacterized protein. (328 aa)
sta-2Signal transducer and activator of transcription b; Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Belongs to the transcription factor STAT family. (567 aa)
K02D7.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (318 aa)
K02E7.10Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
zip-2BZIP domain-containing protein. (308 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
T06D8.10Uncharacterized protein. (1490 aa)
math-39MATH (Meprin-associated Traf homology) domain containing. (300 aa)
snb-1Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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