STRINGSTRING
hda-3 hda-3 lipl-1 lipl-1 his-60 his-60 nhr-80 nhr-80 his-38 his-38 lipl-4 lipl-4 his-18 his-18 his-28 his-28 nhr-49 nhr-49 hat-1 hat-1 cbp-1 cbp-1 sir-2.1 sir-2.1 lipl-3 lipl-3 mdt-15 mdt-15 his-1 his-1 fat-4 fat-4 his-67 his-67 rpl-32 rpl-32 mys-1 mys-1 hlh-30 hlh-30 pod-2 pod-2 Y37B11A.2 Y37B11A.2 pola-1 pola-1 sbp-1 sbp-1 pcaf-1 pcaf-1 fat-1 fat-1 glp-4 glp-4 his-26 his-26 his-10 his-10 his-14 his-14 his-46 his-46 acly-2 acly-2 hda-2 hda-2 acs-19 acs-19 xpf-1 xpf-1 his-37 his-37 acdh-1 acdh-1 acly-1 acly-1 his-50 his-50 fat-7 fat-7 ercc-1 ercc-1 his-31 his-31 his-64 his-64 acs-2 acs-2 fasn-1 fasn-1 his-5 his-5 his-56 his-56
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hda-3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa)
lipl-1Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
his-60Histone H4. (103 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
his-38Histone H4. (103 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
hat-1Hat1_N domain-containing protein. (411 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
sir-2.1NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] (607 aa)
lipl-3Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
his-1Histone H4. (103 aa)
fat-4Delta(5) fatty acid desaturase fat-4; Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position; Belongs to the fatty acid desaturase type 1 family. (447 aa)
his-67Histone H4. (103 aa)
rpl-32Ribosomal Protein, Large subunit. (134 aa)
mys-1Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. (458 aa)
hlh-30BHLH domain-containing protein. (524 aa)
pod-2Uncharacterized protein. (2165 aa)
Y37B11A.2DNA polymerase. (1303 aa)
pola-1DNA polymerase. (1456 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
pcaf-1P300/CBP Associated Factor homolog. (767 aa)
fat-1Omega-3 fatty acid desaturase fat-1; Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. (402 aa)
glp-4Valine--tRNA ligase. (1050 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-14Histone H4. (103 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
acly-2ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1099 aa)
hda-2Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] (507 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
xpf-1ERCC4 domain-containing protein. (935 aa)
his-37Histone H4. (103 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
acly-1Probable ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1106 aa)
his-50Histone H4. (103 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
ercc-1ERCC (DNA excision repair protein) homolog. (262 aa)
his-31Histone H4. (103 aa)
his-64Histone H4. (103 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
his-5Histone H4. (103 aa)
his-56Histone H4. (103 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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