STRINGSTRING
daf-16 daf-16 hsp-70 hsp-70 hsp-3 hsp-3 haf-1 haf-1 C34B2.10 C34B2.10 ttc-1 ttc-1 lonp-1 lonp-1 sdha-2 sdha-2 hsp-6 hsp-6 C46F11.6 C46F11.6 hsp-90 hsp-90 hsp-1 hsp-1 ama-1 ama-1 hsp-4 hsp-4 F44E5.4 F44E5.4 ubl-5 ubl-5 idh-1 idh-1 ubl-1 ubl-1 gst-4 gst-4 mtl-1 mtl-1 atp-6 atp-6 rol-6 rol-6 atf-5 atf-5 skn-1 skn-1 gst-13 gst-13 hsp-16.11 hsp-16.11 hsp-16.1 hsp-16.1 hsp-60 hsp-60 hsp-16.2 hsp-16.2 hsf-1 hsf-1 atfs-1 atfs-1 dve-1 dve-1 clpp-1 clpp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
haf-1HAlF transporter (PGP related). (677 aa)
C34B2.10Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (105 aa)
ttc-1TPR_REGION domain-containing protein. (207 aa)
lonp-1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...] (971 aa)
sdha-2Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
hsp-6Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family. (657 aa)
C46F11.6Ubiquitin-like protein. (121 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
hsp-1Heat shock 70 kDa protein A. (640 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
F44E5.4Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa)
ubl-5Ubiquitin-like protein 5. (73 aa)
idh-1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
gst-4Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
atp-6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (199 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
atf-5BZIP domain-containing protein. (208 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
gst-13Glutathione S-Transferase. (208 aa)
hsp-16.11Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
hsp-16.1Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
hsp-60Chaperonin homolog Hsp-60, mitochondrial; Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity). (568 aa)
hsp-16.2Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. (145 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
atfs-1Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] (488 aa)
dve-1Homeobox domain-containing protein. (468 aa)
clpp-1ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. (221 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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