STRINGSTRING
his-26 his-26 his-46 his-46 arle-14 arle-14 gei-8 gei-8 hlh-25 hlh-25 ceh-48 ceh-48 his-37 his-37 set-8 set-8 his-50 his-50 his-31 his-31 his-64 his-64 hlh-28 hlh-28 hlh-29 hlh-29 cec-4 cec-4 cec-5 cec-5 his-5 his-5 his-56 his-56 his-60 his-60 his-38 his-38 his-18 his-18 his-28 his-28 smo-1 smo-1 lin-61 lin-61 his-1 his-1 his-67 his-67 set-25 set-25 lin-65 lin-65 his-10 his-10 his-14 his-14 xpo-1 xpo-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-26Histone H4. (103 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
arle-14ARF7EP_C domain-containing protein. (204 aa)
gei-8Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. (1778 aa)
hlh-25BHLH domain-containing protein. (268 aa)
ceh-48One cut domain family member. (459 aa)
his-37Histone H4. (103 aa)
set-8SET domain-containing protein. (512 aa)
his-50Histone H4. (103 aa)
his-31Histone H4. (103 aa)
his-64Histone H4. (103 aa)
hlh-28BHLH domain-containing protein. (239 aa)
hlh-29BHLH domain-containing protein. (239 aa)
cec-4Chromo domain-containing protein cec-4; Chromatin anchor protein which binds to methylated lysine residues on histone H3, thereby recruiting heterochromatin to the nuclear periphery. May be required for the correct positioning of chromatin and nucleoli in embryos. (270 aa)
cec-5Chromo domain-containing protein. (374 aa)
his-5Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-60Histone H4. (103 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
lin-61Protein lin-61; Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability. (612 aa)
his-1Histone H4. (103 aa)
his-67Histone H4. (103 aa)
set-25Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9. (714 aa)
lin-65LIN-65L. (728 aa)
his-10Histone H4. (103 aa)
his-14Histone H4. (103 aa)
xpo-1Importin N-terminal domain-containing protein. (1080 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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