STRINGSTRING
his-37 his-37 his-50 his-50 dop-1 dop-1 his-31 his-31 nep-11 nep-11 his-64 his-64 tdp-1 tdp-1 his-5 his-5 his-56 his-56 his-60 his-60 his-38 his-38 his-18 his-18 his-28 his-28 pik-1 pik-1 dop-5 dop-5 nep-2 nep-2 his-46 his-46 his-1 his-1 nep-21 nep-21 his-67 his-67 ace-1 ace-1 vps-34 vps-34 ace-2 ace-2 ace-4 ace-4 his-26 his-26 his-10 his-10 hda-4 hda-4 dop-6 dop-6 sphk-1 sphk-1 nep-1 nep-1 his-14 his-14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-37Histone H4. (103 aa)
his-50Histone H4. (103 aa)
dop-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (460 aa)
his-31Histone H4. (103 aa)
nep-11Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa)
his-64Histone H4. (103 aa)
tdp-1Tar DNA-binding protein homolog 1; RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double- stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion. (414 aa)
his-5Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-60Histone H4. (103 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
pik-1Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. (485 aa)
dop-5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (763 aa)
nep-2Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
his-1Histone H4. (103 aa)
nep-21Neprilysin-21; Probable cell surface protease. (856 aa)
his-67Histone H4. (103 aa)
ace-1Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine. (620 aa)
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa)
ace-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa)
ace-4Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
hda-4Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. (869 aa)
dop-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (682 aa)
sphk-1Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa)
nep-1Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa)
his-14Histone H4. (103 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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