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snx-17 snx-17 abt-4 abt-4 Y42H9AR.1 Y42H9AR.1 laat-1 laat-1 rab-35 rab-35 abt-5 abt-5 hum-8 hum-8 snr-7 snr-7 apb-1 apb-1 pkd-2 pkd-2 sec-24.2 sec-24.2 sar-1 sar-1 sec-16 sec-16 sid-2 sid-2 cnx-1 cnx-1 ZK970.8 ZK970.8 pept-1 pept-1 slcf-1 slcf-1 rab-6.1 rab-6.1 golg-4 golg-4 aman-2 aman-2 abt-6 abt-6 syx-5 syx-5 F54C9.11 F54C9.11 rer-1 rer-1 sdpn-1 sdpn-1 eef-1A.1 eef-1A.1 rab-5 rab-5 snx-27 snx-27 ehbp-1 ehbp-1 smgl-1 smgl-1 czw-1 czw-1 sec-24.1 sec-24.1 abt-2 abt-2 rab-8 rab-8 rab-1 rab-1 abt-1 abt-1 rei-1 rei-1 erm-1 erm-1 nhx-2 nhx-2 arf-1.2 arf-1.2 pmk-1 pmk-1 arf-6 arf-6 apg-1 apg-1 rme-1 rme-1 snx-3 snx-3 rab-7 rab-7 vha-6 vha-6 rab-6.2 rab-6.2 act-5 act-5 rab-10 rab-10 chc-1 chc-1 apa-2 apa-2 tre-2 tre-2 sec-31 sec-31 rol-6 rol-6 pgp-1 pgp-1 ile-1 ile-1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
snx-17Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa)
abt-4ABC Transporter family. (1802 aa)
Y42H9AR.1GRASP55_65 domain-containing protein. (506 aa)
laat-1Lysosomal amino acid transporter 1; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function ; Belongs to the laat-1 family. (311 aa)
rab-35RAB family. (209 aa)
abt-5ABC Transporter family. (1564 aa)
hum-8Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa)
snr-7Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
apb-1AP complex subunit beta. (955 aa)
pkd-2Polycystin-2; Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior. (716 aa)
sec-24.2Yeast SEC homolog. (984 aa)
sar-1GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
sec-16Protein transport protein Sec16. (1232 aa)
sid-2Systemic RNA interference defective protein 2; Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. (311 aa)
cnx-1Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa)
ZK970.8Uncharacterized protein. (143 aa)
pept-1Peptide transporter family 1; Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently a [...] (835 aa)
slcf-1SoLute Carrier Family. (450 aa)
rab-6.1Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
golg-4GRIP domain-containing protein. (1642 aa)
aman-2Alpha-mann_mid domain-containing protein. (1145 aa)
abt-6ABC Transporter family. (252 aa)
syx-5Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa)
F54C9.11Uncharacterized protein. (367 aa)
rer-1Protein RER1 homolog; May be involved in protein transport along the secretory pathway; Belongs to the RER1 family. (191 aa)
sdpn-1SynDaPiN (Synaptic dynamin binding protein) homolog. (495 aa)
eef-1A.1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa)
rab-5RAB family. (208 aa)
snx-27Sorting NeXin. (578 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
smgl-1Uncharacterized protein. (1615 aa)
czw-1Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC8 [...] (778 aa)
sec-24.1Yeast SEC homolog. (1126 aa)
abt-2ABC Transporter family. (2146 aa)
rab-8RAB family. (211 aa)
rab-1RAB family. (205 aa)
abt-1ABC transporter domain-containing protein. (1558 aa)
rei-1Guanine nucleotide exchange factor rei-1; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows. (244 aa)
erm-1FERM domain-containing protein. (564 aa)
nhx-2Na(+)/H(+) exchanger protein 2; Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept- 1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway. (644 aa)
arf-1.2ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
arf-6ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
rme-1Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
snx-3PX domain-containing protein. (162 aa)
rab-7RAB family. (209 aa)
vha-6V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (865 aa)
rab-6.2Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa)
act-5ACTin. (375 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
chc-1Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa)
apa-2AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa)
tre-2Trehalase. (671 aa)
sec-31WD_REPEATS_REGION domain-containing protein. (1083 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
pgp-1Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1321 aa)
ile-1L-type lectin-like domain-containing protein. (492 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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