STRINGSTRING
wrt-1 wrt-1 tol-1 tol-1 dim-1 dim-1 ptr-1 ptr-1 grl-1 grl-1 C27B7.7 C27B7.7 wrt-8 wrt-8 ptr-2 ptr-2 ptr-4 ptr-4 ptr-5 ptr-5 acdh-1 acdh-1 scp-1 scp-1 maoc-1 maoc-1 grd-12 grd-12 ncr-1 ncr-1 ptd-2 ptd-2 ncr-2 ncr-2 rrf-3 rrf-3 grl-12 grl-12 daf-6 daf-6 fasn-1 fasn-1 folt-2 folt-2 grl-27 grl-27 grl-4 grl-4 ptr-8 ptr-8 grd-2 grd-2 ptr-24 ptr-24 wrt-2 wrt-2 mom-4 mom-4 che-14 che-14 elo-1 elo-1 grl-6 grl-6 dhs-28 dhs-28 grd-1 grd-1 daf-16 daf-16 grd-4 grd-4 grd-14 grd-14 grl-7 grl-7 qua-1 qua-1 ptr-16 ptr-16 mom-5 mom-5 grl-22 grl-22 grd-3 grd-3 lit-1 lit-1 pod-2 pod-2 ptr-18 ptr-18 tra-1 tra-1 grl-5 grl-5 daf-22 daf-22 grl-16 grl-16 fat-1 fat-1 nhr-112 nhr-112 grl-21 grl-21 wrt-10 wrt-10 wrt-6 wrt-6 pmt-1 pmt-1 ptc-1 ptc-1 wrt-4 wrt-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
tol-1TIR domain-containing protein. (1221 aa)
dim-1Disorganized muscle protein 1; Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function. (640 aa)
ptr-1SSD domain-containing protein. (956 aa)
grl-1Ground-like domain-containing protein. (348 aa)
C27B7.7Ig-like and fibronectin type-III domain-containing protein C27B7.7. (1456 aa)
wrt-8Warthog protein 8 C-product; Intercellular signal essential for a variety of patterning events during development. (550 aa)
ptr-2SSD domain-containing protein. (933 aa)
ptr-4SSD domain-containing protein. (960 aa)
ptr-5SSD domain-containing protein. (961 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
scp-1SREBP Cleavage activating Protein (SCAP) homolog. (1087 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
grd-12Ground-like domain-containing protein. (285 aa)
ncr-1NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa)
ptd-2SSD domain-containing protein. (936 aa)
ncr-2NPC intracellular cholesterol transporter 1 homolog 2; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1274 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
grl-12Ground-like domain-containing protein. (186 aa)
daf-6SSD domain-containing protein. (913 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
folt-2Folate-like transporter 2; Unlike folt-1, does not appear to act as a folate transporter; Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. (424 aa)
grl-27Ground-like domain-containing protein. (139 aa)
grl-4Ground-like domain-containing protein. (210 aa)
ptr-8SSD domain-containing protein. (890 aa)
grd-2GRounDhog (Hedgehog-like family). (946 aa)
ptr-24SSD domain-containing protein. (892 aa)
wrt-2WaRThog (Hedgehog-like family). (454 aa)
mom-4Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (536 aa)
che-14SSD domain-containing protein. (917 aa)
elo-1Elongation of very long chain fatty acids protein. (288 aa)
grl-6Ground-like domain-containing protein. (240 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
grd-1GRounDhog (Hedgehog-like family). (1160 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
grd-4Ground-like domain-containing protein. (169 aa)
grd-14GRounDhog (Hedgehog-like family). (154 aa)
grl-7Ground-like domain-containing protein. (352 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
ptr-16SSD domain-containing protein. (898 aa)
mom-5Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa)
grl-22Ground-like domain-containing protein. (162 aa)
grd-3Ground-like domain-containing protein. (181 aa)
lit-1Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis. (634 aa)
pod-2Uncharacterized protein. (2165 aa)
ptr-18SSD domain-containing protein. (895 aa)
tra-1Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...] (1110 aa)
grl-5Ground-like domain-containing protein. (220 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
grl-16Ground-like domain-containing protein. (453 aa)
fat-1Omega-3 fatty acid desaturase fat-1; Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown. (402 aa)
nhr-112Nuclear receptor domain-containing protein. (342 aa)
grl-21Ground-like domain-containing protein. (172 aa)
wrt-10WaRThog (Hedgehog-like family). (258 aa)
wrt-6Warthog protein 6 C-product; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (593 aa)
pmt-1Methyltransf_11 domain-containing protein. (484 aa)
ptc-1Protein patched homolog 1; Required but not essential for cytokinesis of mitotically proliferating germ cells. (1408 aa)
wrt-4Warthog protein 4 C-product; Intercellular signal essential for a variety of patterning events during development. (557 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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