STRINGSTRING
znf-207 znf-207 nhr-10 nhr-10 sdha-1 sdha-1 icl-1 icl-1 mthf-1 mthf-1 sod-3 sod-3 hsp-3 hsp-3 acdh-2 acdh-2 sdha-2 sdha-2 acs-19 acs-19 cyc-1 cyc-1 acdh-1 acdh-1 nhr-178 nhr-178 nhr-45 nhr-45 sea-1 sea-1 fasn-1 fasn-1 irg-5 irg-5 ama-1 ama-1 hsp-4 hsp-4 bli-3 bli-3 nhr-68 nhr-68 acdh-3 acdh-3 gst-4 gst-4 gpd-3 gpd-3 unc-119 unc-119 mdl-1 mdl-1 cyp-14A4 cyp-14A4 nhr-114 nhr-114 sbp-1 sbp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
znf-207BED-type domain-containing protein. (341 aa)
nhr-10Nuclear hormone receptor family member nhr-10; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (395 aa)
sdha-1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (646 aa)
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)
mthf-1Probable methylenetetrahydrofolate reductase. (663 aa)
sod-3Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (218 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
sdha-2Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (640 aa)
acs-19Acetyl-coenzyme A synthetase. (680 aa)
cyc-1Cytochrome c domain-containing protein. (285 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
nhr-178Nuclear Hormone Receptor family. (421 aa)
nhr-45Nuclear Hormone Receptor family. (525 aa)
sea-1T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate. (376 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
irg-5CUB_2 domain-containing protein. (343 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
bli-3Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa)
nhr-68NR LBD domain-containing protein. (385 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
gst-4Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa)
gpd-3Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
mdl-1BHLH domain-containing protein. (281 aa)
cyp-14A4CYtochrome P450 family; Belongs to the cytochrome P450 family. (491 aa)
nhr-114NR LBD domain-containing protein; Belongs to the nuclear hormone receptor family. (418 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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