STRINGSTRING
unc-54 unc-54 pmk-1 pmk-1 cht-1 cht-1 fbxa-158 fbxa-158 pals-5 pals-5 rab-3 rab-3 C28G1.5 C28G1.5 pals-22 pals-22 C46A5.4 C46A5.4 vhp-1 vhp-1 nhr-25 nhr-25 tir-1 tir-1 col-12 col-12 lin-26 lin-26 F26F2.1 F26F2.1 tax-2 tax-2 skr-3 skr-3 dpy-7 dpy-7 ptr-24 ptr-24 skr-5 skr-5 K02D7.1 K02D7.1 cul-6 cul-6 pxn-2 pxn-2 unc-119 unc-119 T06D8.10 T06D8.10 snb-1 snb-1 cht-2 cht-2 dpy-10 dpy-10 pals-25 pals-25 chil-27 chil-27 dbl-1 dbl-1 fbxa-75 fbxa-75 cht-4 cht-4 Y37B11A.2 Y37B11A.2 unc-25 unc-25 pola-1 pola-1 eat-2 eat-2 skr-4 skr-4 zip-1 zip-1 grl-21 grl-21 tax-4 tax-4 pxn-1 pxn-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
cht-1Probable endochitinase. (617 aa)
fbxa-158F-box domain-containing protein. (393 aa)
pals-5Protein containing ALS2cr12 (ALS2CR12) signature. (304 aa)
rab-3Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa)
C28G1.5RING-type domain-containing protein. (302 aa)
pals-22Protein containing ALS2cr12 (ALS2CR12) signature. (284 aa)
C46A5.4Uncharacterized protein. (1537 aa)
vhp-1Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa)
nhr-25Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. (572 aa)
tir-1NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa)
col-12Cuticle collagen 12; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (316 aa)
lin-26Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa)
F26F2.1Uncharacterized protein. (663 aa)
tax-2Cyclic nucleotide-binding domain-containing protein. (800 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
dpy-7Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
ptr-24SSD domain-containing protein. (892 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
K02D7.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (318 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
pxn-2PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
T06D8.10Uncharacterized protein. (1490 aa)
snb-1Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa)
cht-2CHiTinase; Belongs to the glycosyl hydrolase 18 family. (626 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
pals-25Protein containing ALS2cr12 (ALS2CR12) signature. (305 aa)
chil-27CHItinase-Like. (407 aa)
dbl-1TGF_BETA_2 domain-containing protein. (365 aa)
fbxa-75FTH domain-containing protein. (321 aa)
cht-4Glyco_18 domain-containing protein; Belongs to the glycosyl hydrolase 18 family. (360 aa)
Y37B11A.2DNA polymerase. (1303 aa)
unc-25Glutamic acid decarboxylase. (508 aa)
pola-1DNA polymerase. (1456 aa)
eat-2Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
zip-1BZIP transcription factor family. (480 aa)
grl-21Ground-like domain-containing protein. (172 aa)
tax-4Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa)
pxn-1Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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