27 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpx-8	Glutathione PeroXidase. (145 aa)
	gpx-4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
	sbp-1	BHLH domain-containing protein. (1113 aa)
	pola-1	DNA polymerase. (1456 aa)
	Y37B11A.2	DNA polymerase. (1303 aa)
	fat-5	Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
	fat-6	Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
	gpx-6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
	mdt-15	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
	gpx-2	Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
	gpx-7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
	cpt-4	Carn_acyltransf domain-containing protein. (748 aa)
	nhr-49	Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
	acdh-8	Acyl CoA DeHydrogenase. (412 aa)
	gpx-5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
	gpx-3	Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
	art-1	Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...] (308 aa)
	ech-1.1	Enoyl-CoA Hydratase. (755 aa)
	acox-1.2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	fat-7	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
	elo-2	Elongation of very long chain fatty acids protein. (274 aa)
	gpx-1	Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
	acs-2	Fatty Acid CoA Synthetase family. (618 aa)
	ppt-1	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
	acs-1	Fatty Acid CoA Synthetase family. (623 aa)
	acaa-2	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	lipl-4	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Y37B11A.2	pola-1	Y37B11A.2a.1	Y47D3A.29b.1	DNA polymerase.	DNA polymerase.	0.771
acaa-2	acdh-8	F53A2.7.2	K05F1.3.1	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl CoA DeHydrogenase.	0.979
acaa-2	acox-1.2	F53A2.7.2	F08A8.2.1	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.969
acaa-2	acs-1	F53A2.7.2	F46E10.1a.1	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty Acid CoA Synthetase family.	0.489
acaa-2	acs-2	F53A2.7.2	F28F8.2.1	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty Acid CoA Synthetase family.	0.651
acaa-2	ech-1.1	F53A2.7.2	C29F3.1.1	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA Hydratase.	0.995
acdh-8	acaa-2	K05F1.3.1	F53A2.7.2	Acyl CoA DeHydrogenase.	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	0.979
acdh-8	acox-1.2	K05F1.3.1	F08A8.2.1	Acyl CoA DeHydrogenase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.467
acdh-8	acs-1	K05F1.3.1	F46E10.1a.1	Acyl CoA DeHydrogenase.	Fatty Acid CoA Synthetase family.	0.428
acdh-8	acs-2	K05F1.3.1	F28F8.2.1	Acyl CoA DeHydrogenase.	Fatty Acid CoA Synthetase family.	0.531
acdh-8	ech-1.1	K05F1.3.1	C29F3.1.1	Acyl CoA DeHydrogenase.	Enoyl-CoA Hydratase.	0.968
acdh-8	fat-7	K05F1.3.1	F10D2.9.1	Acyl CoA DeHydrogenase.	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA.	0.480
acdh-8	lipl-4	K05F1.3.1	K04A8.5a.1	Acyl CoA DeHydrogenase.	Lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.443
acox-1.2	acaa-2	F08A8.2.1	F53A2.7.2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family.	0.969
acox-1.2	acdh-8	F08A8.2.1	K05F1.3.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl CoA DeHydrogenase.	0.467
acox-1.2	acs-1	F08A8.2.1	F46E10.1a.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Fatty Acid CoA Synthetase family.	0.773
acox-1.2	acs-2	F08A8.2.1	F28F8.2.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Fatty Acid CoA Synthetase family.	0.634
acox-1.2	ech-1.1	F08A8.2.1	C29F3.1.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Enoyl-CoA Hydratase.	0.905
acox-1.2	fat-7	F08A8.2.1	F10D2.9.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA.	0.646
acox-1.2	lipl-4	F08A8.2.1	K04A8.5a.1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.443