STRINGSTRING
his-60 his-60 his-56 his-56 his-14 his-14 his-10 his-10 his-26 his-26 ZK1067.2 ZK1067.2 atg-5 atg-5 hda-10 hda-10 his-67 his-67 his-1 his-1 hda-3 hda-3 his-28 his-28 his-18 his-18 his-38 his-38 his-5 his-5 hda-5 hda-5 aqp-4 aqp-4 hrpk-1 hrpk-1 his-64 his-64 his-31 his-31 his-50 his-50 his-37 his-37 mak-2 mak-2 hda-11 hda-11 sphk-1 sphk-1 pld-1 pld-1 his-46 his-46
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-60Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-14Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-26Histone H4. (103 aa)
ZK1067.2NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. (2443 aa)
atg-5Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] (275 aa)
hda-10Hist_deacetyl domain-containing protein. (517 aa)
his-67Histone H4. (103 aa)
his-1Histone H4. (103 aa)
hda-3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa)
his-28Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-38Histone H4. (103 aa)
his-5Histone H4. (103 aa)
hda-5Hist_deacetyl domain-containing protein. (508 aa)
aqp-4AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family. (273 aa)
hrpk-1Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. (397 aa)
his-64Histone H4. (103 aa)
his-31Histone H4. (103 aa)
his-50Histone H4. (103 aa)
his-37Histone H4. (103 aa)
mak-2MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (366 aa)
hda-11Hist_deacetyl domain-containing protein. (334 aa)
sphk-1Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). (473 aa)
pld-1Phospholipase. (1427 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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