STRINGSTRING
nck-1 nck-1 viro-2 viro-2 sid-3 sid-3 pals-5 pals-5 dpy-3 dpy-3 sur-7 sur-7 fat-7 fat-7 elo-2 elo-2 drh-1 drh-1 drl-1 drl-1 daf-3 daf-3 elo-5 elo-5 elo-6 elo-6 nhr-80 nhr-80 rde-1 rde-1 nhr-49 nhr-49 mdt-15 mdt-15 daf-16 daf-16 fat-6 fat-6 fat-5 fat-5 rps-20 rps-20 sbp-1 sbp-1 hipr-1 hipr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nck-1NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. (395 aa)
viro-2WH1 domain-containing protein. (616 aa)
sid-3Tyrosine-protein kinase sid-3; Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues. (1237 aa)
pals-5Protein containing ALS2cr12 (ALS2CR12) signature. (304 aa)
dpy-3Col_cuticle_N domain-containing protein. (302 aa)
sur-7SUppressor of activated let-60 Ras. (371 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
elo-2Elongation of very long chain fatty acids protein. (274 aa)
drh-1Dicer-related helicase. (1037 aa)
drl-1Protein drl-1; Negatively regulates lifespan and health span probably by participating in nutrient sensing. (589 aa)
daf-3Dwarfin sma. (895 aa)
elo-5Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
elo-6Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). (274 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
rps-20Ribosomal_S10 domain-containing protein. (117 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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