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kin-1 kin-1 lipl-5 lipl-5 iglr-2 iglr-2 nhr-13 nhr-13 daf-2 daf-2 ser-6 ser-6 sbp-1 sbp-1 acdh-11 acdh-11 paqr-2 paqr-2 daf-28 daf-28 spl-3 spl-3 fat-5 fat-5 pck-1 pck-1 hlh-30 hlh-30 fat-6 fat-6 nhr-69 nhr-69 nhr-66 nhr-66 cgt-1 cgt-1 ech-6 ech-6 cpl-1 cpl-1 dhs-3 dhs-3 aak-2 aak-2 daf-16 daf-16 mdt-15 mdt-15 pck-2 pck-2 acs-15 acs-15 R01B10.6 R01B10.6 slc-25A10 slc-25A10 cpt-4 cpt-4 nhr-49 nhr-49 mod-1 mod-1 ser-3 ser-3 mboa-2 mboa-2 nhr-80 nhr-80 pck-3 pck-3 hlh-11 hlh-11 elo-1 elo-1 mxl-3 mxl-3 acs-4 acs-4 ets-4 ets-4 ins-1 ins-1 fat-7 fat-7 atx-2 atx-2 pyc-1 pyc-1 acdh-1 acdh-1 nhr-64 nhr-64 paqr-1 paqr-1 vit-2 vit-2 rege-1 rege-1 acdh-2 acdh-2 pnk-1 pnk-1 atgl-1 atgl-1 daf-7 daf-7 mboa-1 mboa-1 rbg-3 rbg-3 spl-2 spl-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
iglr-2Immunoglobulin domain and leucine-rich repeat-containing protein 2. (773 aa)
nhr-13Nuclear hormone receptor family member nhr-13; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (425 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
ser-6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
acdh-11Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. (617 aa)
paqr-2Progestin and AdipoQ Receptor family. (581 aa)
daf-28Uncharacterized protein. (97 aa)
spl-3Sphingosine Phosphate Lyase. (606 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
pck-1PEPCK_GTP domain-containing protein. (651 aa)
hlh-30BHLH domain-containing protein. (524 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
nhr-69Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. (373 aa)
nhr-66Nuclear Hormone Receptor family. (733 aa)
cgt-1Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. (466 aa)
ech-6Probable enoyl-CoA hydratase, mitochondrial. (288 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
dhs-3Protein dhs-3; May play a role in lipid droplet formation. May modulate triglyceride levels; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
aak-25'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
pck-2Phosphoenolypyruvate CarboxyKinase. (654 aa)
acs-15Fatty Acid CoA Synthetase family. (703 aa)
R01B10.6Uncharacterized protein. (274 aa)
slc-25A10Oxoglutarate/malate carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (290 aa)
cpt-4Carn_acyltransf domain-containing protein. (748 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
mod-1Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (489 aa)
ser-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (610 aa)
mboa-2O-acyltransferase. (498 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
pck-3Phosphoenolypyruvate CarboxyKinase. (624 aa)
hlh-11Helix-loop-helix protein 11. (431 aa)
elo-1Elongation of very long chain fatty acids protein. (288 aa)
mxl-3BHLH domain-containing protein. (235 aa)
acs-4Fatty Acid CoA Synthetase family. (731 aa)
ets-4Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too [...] (437 aa)
ins-1IlGF domain-containing protein. (109 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
atx-2Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] (1026 aa)
pyc-1Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
nhr-64Nuclear hormone receptor family member nhr-64; Orphan nuclear receptor. (375 aa)
paqr-1Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family. (440 aa)
vit-2Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa)
rege-1Endoribonuclease rege-1; Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript. Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes. May play a role in the clearance of apoptotic cell corpses. (634 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
pnk-1PaNtothenate Kinase. (449 aa)
atgl-1Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] (751 aa)
daf-7Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa)
mboa-1O-acyltransferase. (467 aa)
rbg-3Rab-GAP TBC domain-containing protein. (585 aa)
spl-2Sphingosine Phosphate Lyase. (542 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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