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bgal-1 bgal-1 rpl-26 rpl-26 skih-2 skih-2 rps-10 rps-10 C52E12.1 C52E12.1 hsp-90 hsp-90 C46F11.6 C46F11.6 ufc-1 ufc-1 ubc-1 ubc-1 ubr-1 ubr-1 rps-3 rps-3 hsp-70 hsp-70 ufl-1 ufl-1 rps-20 rps-20 abce-1 abce-1 oaz-1 oaz-1 ufm-1 ufm-1 pelo-1 pelo-1 uba-5 uba-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bgal-1Beta-galactosidase. (653 aa)
rpl-2660S ribosomal protein L26. (142 aa)
skih-2SKI (Yeast SuperKIller) Helicase homolog. (1266 aa)
rps-10S10_plectin domain-containing protein. (149 aa)
C52E12.1RING-type domain-containing protein. (925 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
C46F11.6Ubiquitin-like protein. (121 aa)
ufc-1Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm-1. The intermediate is formed via a thioester linkage (By similarity). (162 aa)
ubc-1Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
ubr-1E3 ubiquitin-protein ligase ubr-1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development. Negatively regulates glutamate metabolism through the aspartate aminotrans [...] (2058 aa)
rps-340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (247 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
ufl-1E3 UFM1-protein ligase 1 homolog; E3 UFM1-protein ligase that mediates ufmylation of target proteins. (735 aa)
rps-20Ribosomal_S10 domain-containing protein. (117 aa)
abce-1ABC transporter, class E. (610 aa)
oaz-1Ornithine decarboxylase antizyme; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome. (159 aa)
ufm-1Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer (By similarity). The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc- 1, and probably the ufm-1-ligase E3 enzyme ufl-1. Belongs to the UFM1 family. (94 aa)
pelo-1Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity. (381 aa)
uba-5Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. (419 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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