node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | dpy-10 | T25C8.2.2 | T14B4.7.1 | ACTin. | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. | 0.417 |
act-5 | unc-119 | T25C8.2.2 | M142.1c.1 | ACTin. | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.776 |
act-5 | unc-54 | T25C8.2.2 | F11C3.3.2 | ACTin. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.855 |
bed-3 | blmp-1 | F25H8.6.1 | F25D7.3a.1 | Zinc finger BED domain-containing protein 3; Probable transcription factor involved in vulval organogenesis. During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1. Plays a role in larval molting. | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] | 0.721 |
blmp-1 | bed-3 | F25D7.3a.1 | F25H8.6.1 | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] | Zinc finger BED domain-containing protein 3; Probable transcription factor involved in vulval organogenesis. During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1. Plays a role in larval molting. | 0.721 |
blmp-1 | nhr-25 | F25D7.3a.1 | F11C1.6a.1 | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] | Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. | 0.616 |
dpy-10 | act-5 | T14B4.7.1 | T25C8.2.2 | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. | ACTin. | 0.417 |
dpy-10 | unc-119 | T14B4.7.1 | M142.1c.1 | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.815 |
dpy-10 | unc-54 | T14B4.7.1 | F11C3.3.2 | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.670 |
myrf-1 | nhr-23 | F59B10.1.1 | C01H6.5a.1 | Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.484 |
nhr-23 | myrf-1 | C01H6.5a.1 | F59B10.1.1 | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] | 0.484 |
nhr-23 | nhr-25 | C01H6.5a.1 | F11C1.6a.1 | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. | 0.534 |
nhr-25 | blmp-1 | F11C1.6a.1 | F25D7.3a.1 | Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] | 0.616 |
nhr-25 | nhr-23 | F11C1.6a.1 | C01H6.5a.1 | Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. | Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.534 |
nlp-29 | tir-1 | B0213.4.1 | F13B10.1f.1 | Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family. | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] | 0.698 |
rde-1 | unc-119 | K08H10.7.1 | M142.1c.1 | RNA interference promoting factor RDE-1. | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.758 |
rde-1 | unc-54 | K08H10.7.1 | F11C3.3.2 | RNA interference promoting factor RDE-1. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.700 |
tir-1 | nlp-29 | F13B10.1f.1 | B0213.4.1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] | Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family. | 0.698 |
tir-1 | unc-119 | F13B10.1f.1 | M142.1c.1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. | 0.433 |
tir-1 | unc-54 | F13B10.1f.1 | F11C3.3.2 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.662 |