STRINGSTRING
gld-1 gld-1 unc-83 unc-83 nuo-6 nuo-6 laat-1 laat-1 scav-3 scav-3 his-72 his-72 ced-7 ced-7 lmn-1 lmn-1 rrf-3 rrf-3 unc-54 unc-54 unc-119 unc-119
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gld-1Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa)
unc-83Nuclear migration protein unc-83; Cargo-specific adapter that is involved in nuclear migration during development and thereafter. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations. Moreover [...] (1041 aa)
nuo-6NADH Ubiquinone Oxidoreductase. (172 aa)
laat-1Lysosomal amino acid transporter 1; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function ; Belongs to the laat-1 family. (311 aa)
scav-3SCAVenger receptor (CD36 family) related; Belongs to the CD36 family. (534 aa)
his-72Histone H3.3 type 2. (151 aa)
ced-7ABC transporter ced-7; Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells. (1758 aa)
lmn-1Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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