(22 nodes) (2023) Implication of Vegetable Oil-Derived Hydroxynonenal in the Lysosomal Cell Death for Lifestyle-Related Diseases. network (Caenorhabditis elegans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	cpr-2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
	cpr-4	Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
	F57F5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
	asp-3	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
	scav-3	SCAVenger receptor (CD36 family) related; Belongs to the CD36 family. (534 aa)
	cpr-5	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
	W07B8.4	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
	cpr-8	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
	pho-4	Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family. (452 aa)
	pho-14	Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family. (440 aa)
	cpr-3	Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
	asp-4	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
	F26C11.1	Putative acid phosphatase F26C11.1. (435 aa)
	F32H5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
	pho-10	Putative acid phosphatase 10. (411 aa)
	pho-11	Putative acid phosphatase 11. (413 aa)
	cpr-6	Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
	C27A2.12	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (460 aa)
	pho-12	Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family. (407 aa)
	cpr-1	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
	pho-1	Intestinal acid phosphatase; Acid phosphatase required for normal growth and development. Specifically required for normal gut differentiation. (449 aa)
	pho-13	Intestinal acid PHOsphatase; Belongs to the histidine acid phosphatase family. (446 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F32H5.1	asp-3	F32H5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.940
F32H5.1	asp-4	F32H5.1.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.934
F57F5.1	asp-3	F57F5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.980
F57F5.1	asp-4	F57F5.1.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.937
F57F5.1	cpr-1	F57F5.1.1	C52E4.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.670
F57F5.1	cpr-5	F57F5.1.1	W07B8.5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.613
W07B8.4	asp-3	W07B8.4a.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.930
W07B8.4	asp-4	W07B8.4a.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.932
asp-3	F32H5.1	H22K11.1.1	F32H5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.940
asp-3	F57F5.1	H22K11.1.1	F57F5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.980
asp-3	W07B8.4	H22K11.1.1	W07B8.4a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.930
asp-3	asp-4	H22K11.1.1	R12H7.2.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.916
asp-3	cpr-1	H22K11.1.1	C52E4.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.970
asp-3	cpr-2	H22K11.1.1	F36D3.9.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.929
asp-3	cpr-3	H22K11.1.1	T10H4.12.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family.	0.933
asp-3	cpr-4	H22K11.1.1	F44C4.3.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family.	0.963
asp-3	cpr-5	H22K11.1.1	W07B8.5.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.962
asp-3	cpr-6	H22K11.1.1	C25B8.3a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family.	0.949
asp-3	cpr-8	H22K11.1.1	W07B8.1a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.933
asp-4	F32H5.1	R12H7.2.1	F32H5.1.1	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.934