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| | snr-7 | Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa) |
| | faah-1 | Fatty acid amide hydrolase 1; Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Facilitates axon regeneration after injury by degradating inh [...] (572 aa) |
| | cyn-10 | Peptidyl-prolyl cis-trans isomerase 10; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (161 aa) |
| | eat-6 | Sodium/potassium-transporting ATPase subunit alpha. (996 aa) |
| | mtrr-1 | Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state. (682 aa) |
| | lys-7 | Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa) |
| | henn-1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa) |
| | mthf-1 | Probable methylenetetrahydrofolate reductase. (663 aa) |
| | cbl-1 | Cystathionine Beta Lyase. (451 aa) |
| | akt-1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa) |
| | hrde-1 | Uncharacterized protein C16C10.3. (1032 aa) |
| | fln-2 | FiLamiN (Actin binding protein) homolog. (3672 aa) |
| | rmd-2 | TPR_REGION domain-containing protein. (378 aa) |
| | nex-3 | Annexin. (317 aa) |
| | vha-16 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa) |
| | acs-19 | Acetyl-coenzyme A synthetase. (680 aa) |
| | cle-1 | CoLlagen with Endostatin domain. (1175 aa) |
| | mig-6 | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa) |
| | vit-2 | Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa) |
| | col-14 | Cuticle collagen 14; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (345 aa) |
| | snr-4 | Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). (118 aa) |
| | rpt-1 | 26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa) |
| | ftn-1 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (170 aa) |
| | acdh-1 | Acyl CoA DeHydrogenase. (427 aa) |
| | acs-22 | Fatty Acid CoA Synthetase family. (655 aa) |
| | mans-1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (540 aa) |
| | hoe-1 | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Involved in germline proliferation. May be required for both mitosis and meiosis in germ cells. (833 aa) |
| | mog-5 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1200 aa) |
| | acox-1.2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa) |
| | unc-115 | Uncharacterized protein. (639 aa) |
| | sod-2 | Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (221 aa) |
| | vha-12 | Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Required for necrotic cell death and epidermal cell fusion. (491 aa) |
| | eef-2 | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic trans [...] (852 aa) |
| | pcca-1 | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] (724 aa) |
| | asp-13 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa) |
| | dpy-13 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. (302 aa) |
| | cpz-1 | Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa) |
| | nol-10 | NUC153 domain-containing protein. (754 aa) |
| | rps-11 | Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family. (155 aa) |
| | cpn-4 | Calponin-homology (CH) domain-containing protein. (154 aa) |
| | abts-1 | Anion exchange protein. (1215 aa) |
| | F53F4.11 | Uncharacterized protein. (543 aa) |
| | duox-2 | DUal OXidase. (1503 aa) |
| | F53H1.1 | Uncharacterized protein. (970 aa) |
| | pat-10 | Paralysed Arrest at Two-fold. (161 aa) |
| | pmt-2 | Phosphoethanolamine MethylTransferase. (437 aa) |
| | nath-10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1043 aa) |
| | nkb-3 | Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size. (317 aa) |
| | bli-3 | Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...] (1497 aa) |
| | rps-1 | 40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (257 aa) |
| | lys-4 | LYSozyme. (214 aa) |
| | F58B3.4 | NUC153 domain-containing protein. (601 aa) |
| | suox-1 | Cytochrome b5 heme-binding domain-containing protein. (541 aa) |
| | cpi-1 | Cystatin cpi-1; Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Does not inhibit asparaginyl endopeptidase. May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation. Belongs to the cystatin family. (139 aa) |
| | rnp-2 | RNP (RRM RNA binding domain) containing. (206 aa) |
| | asp-14 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa) |
| | unc-70 | Spectrin beta chain; Belongs to the spectrin family. (2326 aa) |
| | sca-1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa) |
| | myo-3 | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa) |
| | unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa) |
| | metr-1 | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1249 aa) |
| | prdx-3 | Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (226 aa) |
| | hacd-1 | Hydroxy-Acyl-CoA Dehydrogenase. (299 aa) |
| | pck-2 | Phosphoenolypyruvate CarboxyKinase. (654 aa) |
| | daf-16 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa) |
| | lmtr-5 | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa) |
| | rps-16 | 40S ribosomal protein S16. (144 aa) |
| | act-3 | Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | col-166 | Col_cuticle_N domain-containing protein. (301 aa) |
| | cct-7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (535 aa) |
| | glh-4 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. (1156 aa) |
| | asp-2 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (429 aa) |
| | skn-1 | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa) |
| | T20B12.7 | Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (238 aa) |
| | pat-6 | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa) |
| | act-5 | ACTin. (375 aa) |
| | pod-2 | Uncharacterized protein. (2165 aa) |
| | lev-11 | Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa) |
| | ppw-2 | Piwi-like protein; Belongs to the argonaute family. (975 aa) |
| | gsk-3 | Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (362 aa) |
| | Y18D10A.9 | Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins; Belongs to the WD repeat CIA1 family. (337 aa) |
| | lys-1 | Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection. (298 aa) |
| | Y37D8A.19 | Uncharacterized protein. (101 aa) |
| | crt-1 | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa) |
| | prdx-6 | Thioredoxin domain-containing protein. (231 aa) |
| | rps-28 | 40S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (65 aa) |
| | mvk-1 | MeValonate Kinase. (614 aa) |
| | nuo-5 | NADH Ubiquinone Oxidoreductase; Belongs to the complex I 75 kDa subunit family. (729 aa) |
| | rho-1 | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa) |
| | mrpl-55 | Mitochondrial Ribosomal Protein, Large. (125 aa) |
| | fln-1 | Calponin-homology (CH) domain-containing protein. (2259 aa) |
| | Y69A2AR.18 | Uncharacterized protein. (313 aa) |
| | lin-17 | Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | cox-6B | Cytochrome OXidase assembly protein. (121 aa) |
| | cyn-3 | Peptidyl-prolyl cis-trans isomerase 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (173 aa) |
| | ncx-3 | Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (830 aa) |
| | ZC373.2 | Uncharacterized protein. (104 aa) |
| | pmt-1 | Methyltransf_11 domain-containing protein. (484 aa) |
| | tnc-2 | Troponin C, isoform 2; Belongs to the troponin C family. (160 aa) |
